Monday, May 12


PLUS: 185 new Studies from 11/1 to Friday 11/15 Start at the Bottom: 

Multiple Sclerosis International Federation: Stimulating international cooperation in research.The MS International Federation (MSIF), established in 1967, links the activities of over 85 national multiple sclerosis (MS) societies worldwide. Over those 45 years, and particularly in the last 20, it has seen dramatic changes in our understanding, treatment, and multidisciplinary management of people with MS.

Multiple sclerosis research: diagnostics, disease-modifying treatments, and emerging therapies.

Effects of walking direction and cognitive challenges on gait in persons with multiple sclerosis.

Long-term impact of interferon beta-1b in patients with CIS: 8-year follow-up of BENEFIT.

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.

Dalfampridine improves walking speed, walking endurance, and
Neuroimaging biomarkers of neurodegenerative diseases and dementia.

community participation in veterans with multiple sclerosis: a longitudinal cohort study.

Efficacy and safety of BG-12 (dimethyl fumarate) and other disease modifying therapies for the treatment of relapsing-remitting multiple sclerosis: a systematic review and mixed treatment comparison.

Low contrast visual acuity testing is associated with cognitive performance in multiple sclerosis: a cross-sectional pilot study.
Our data show that: a) cognitive impairment and performance in visual function tests such as low contrast sensitivity testing are associated; b) the main cognitive domains correlating with visual test performance are information processing speed and, to a lesser degree, memory; This preliminary data needs to be substantiated in further studies investigating patients with a higher cognitive burden, healthy controls and in longitudinal settings.

Retinal Nerve Fiber Layer Thickness, Brain Atrophy, and Disability in Multiple Sclerosis Patients.

Review of laquinimod and its therapeutic potential in multiple sclerosis.

Teriflunomide: A Review of Its Use in Relapsing Multiple Sclerosis.

Effect of treadmill training on fatigue in multiple sclerosis: a pilot study.

The Regulation of Reactive Changes Around Multiple Sclerosis Lesions by Phosphorylated Signal Transducer and Activator of Transcription.

185 STUDIES FROM 11/1 to Friday 11/15 are below:  

It is well documented that disability accumulation in multiple sclerosis is correlated with axonal injury and that the extent of axonal injury is correlated with the degree of inflammation. However, the interdependence between focal inflammation, diffuse inflammation and neurodegeneration, and their relative contribution to clinical deficits, remains ambiguous.

PRO measures were improved with natalizumab in a real-world setting. The improvements were observed as early as after 3 months and sustained over a 12-month period. The improvements in PROs show that, in clinical practice, the clinical benefits of natalizumab are translated into patient-reported benefits.

The association between MS disease and the MSRV-type HERV-W element now appears quite strong, as evidenced ex-vivo from serum and PBMC with post-mortem confirmation in brain lesions. Chronic progressive MS, RRMS and clinically isolated syndrome show different ELISA (Enzyme-Linked Immunosorbent Assay) and/or PCR profiles suggestive of an increase with disease evolution, and amplicon sequencing confirms the association with particular HERV-W elements.

Differential diagnosis leading to MS or alternatives is complex and a strong evidence base is lacking. Consensus-determined guidelines provide a practical path for diagnosis and will be useful for the non-MS specialist neurologist. Recommendations are made for future research to validate and support these guidelines. Guidance on the differential diagnosis process when MS is under consideration will enhance diagnostic accuracy and precision.

We demonstrated for the first time, albeit only with preliminary data, the aprioristic possibility of distinguishing naive and IFN-treated MS groups from controls, and naive from IFN-treated MS patients using a blood sample-based methodology (i.e. proteomics) alone. The functional profile of the identified molecules provides new pathophysiological insight into MS. Future development of these techniques could open up novel applications in terms of molecular diagnosis and therapy monitoring in MS patients.

These results do not support a major role of stress in the development of the disease, but repeated and more focused measures of stress are needed to firmly exclude stress as a potential risk factor for MS.

Poor sleep is common in patients with MS. Early identification and treatment of modifiable risk factors may improve sleep and quality of life in MS.

Our findings, show no correlation between EA, CD and postpartum relapses and disability. Therefore these procedures can safely be applied in MS patients. On the other hand, post-partum relapses are significantly associated with increased disability, which calls for the need of preventive therapies after delivery.

Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab are DNA-JC virus positive.
Objective Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection.

Evaluation of changes in retinal nerve fiber layer thickness and visual functions in cases of optic neuritis and multiple sclerosis.
RNFL thickness is reduced in ON and MS cases in a pattern similar to Caucasians and is associated with the magnitude of impairment of other visual parameters. Contrast sensitivity and stereoacuity are useful tests to identify subclinical optic nerve involvement in multiple sclerosis.

Utilization of physical rehabilitation among people with multiple sclerosis.
Rehabilitation of MS patients is not systematically provided, especially in early stages of disease when best results can be achieved.

Treatment patterns in multiple sclerosis: administrative claims analysis over 10 years.
Changes in treatment patterns in the first half of the observation period were reflective of the addition of IFNβ-1a SC to the market in 2002. Following the 2003 and 2008 anchor prescriptions there were differences in treatment patterns, with more IFNβ-1a IM users being changed to IFNβ-1a SC after the 2003 anchor DMT, and more of each of the interferons and NZ being changed to GA following the 2008 anchor DMT. With the introduction of oral therapies for MS, treatment patterns will again be impacted.

Factors related to difficulties with employment in patients with multiple sclerosis: a review of 2002-2011 literature.
We assess the knowledge available on the difficulties experienced by multiple sclerosis (MS) patients in work-related activities. A literature review was carried out using the keywords 'multiple sclerosis' and 'employment' or 'work' through PubMed and EMBASE.

Level of mobility limitations and falls status in persons with multiple sclerosis.
The current findings highlight that fall rates including recurrent fall prevalence is not uniform across mobility aid categories in persons with MS. Those using bilateral assistance for gait have the highest prevalence of fallers and those with walking limitations and not yet using an aid had the greatest prevalence of multiple falls.

Multiple sclerosis starting before the age of 18 years: the Brazilian experience.

Prevalence of multiple sclerosis in Verona, Italy: an epidemiological and genetic study.
Indications for hospitalization and in-hospital mortality in Thai systemic sclerosis.

The month of birth effect in multiple sclerosis: systematic review, meta-analysis and effect of latitude.

Epileptic seizures in Japanese patients with multiple sclerosis and neuromyelitis optica.

Multiple Sclerosis International Federation: Stimulating international cooperation in research.

[Resources and Self-Management Skills in Multiple Sclerosis Patients - Can the Scale Structure of the Questionnaire FERUS be Replicated?]

Single-Institution Retrospective Series of Gamma Knife Radiosurgery in the Treatment of Multiple Sclerosis-Related Trigeminal Neuralgia: Factors that Predict Efficacy.

Fully automatic detection of deep white matter T1 hypointense lesions in multiple sclerosis.

A decade of data for the uk multiple sclerosis risk-sharing scheme.

Respiratory tract rather than cutaneous atopic allergy inversely associate with multiple sclerosis: a case-control study.

Neuroborreliosis during natalizumab treatment in multiple sclerosis.

Impact of disease-modifying therapies on the survival of patients with multiple sclerosis in Taiwan, 1997-2008.
The results of this study support the notion that DMTs can improve the survival of patients with MS, and show that individuals with the risk factors of older age, rural residence and lower economic status had a higher MS-related mortality risk in Taiwan.

Detection of B-cell populations with monotypic light chain expression in cerebrospinal fluid specimens from patients with multiple sclerosis by polychromatic flow cytometry.

Preliminary study related the incidence of methylprednisolone pulse therapy in patients visited multiple sclerosis clinic located at the isfahan kashani hospital.

Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development.
Among those with mild to moderate disability from MS, there is sufficient evidence that exercise training is effective for improving both aerobic capacity and muscular strength. Exercise may improve mobility, fatigue, and health-related quality of life.

Incidence of multiple sclerosis in multiple racial and ethnic groups.
Our findings do not support the widely accepted assertion that blacks have a lower risk of MS than whites. A possible explanation for our findings is that people with darker skin tones have lower vitamin D levels and thereby an increased risk of MS, but this would not explain why Hispanics and Asians have a lower risk of MS than whites or why the higher risk of MS among blacks was found only among women.

Month of birth and risk of multiple sclerosis in a Portuguese population.

Squinting through layers of fog: assessing the cost effectiveness of treatments for multiple sclerosis.
There are many complexities for those designing and reporting cost-effectiveness studies of treatments for MS. Analysts, and ultimately decision makers, face multiple data and methodological challenges. Policy makers, technology developers, clinicians, patients and researchers need to acknowledge and address these challenges and to consider recommendations that will improve the current scenario. There  is a need for further research that can constructively inform decision-making regarding the funding of treatments for MS.

Increased incidence of multiple sclerosis in the Veneto region, Italy.

A novel method for calculating prevalence of multiple sclerosis in Australia.

Newly diagnosed multiple sclerosis in state of Qatar.
MS in Qatar is an emerging disorder especially in the native population. The pattern of disease differs from other Middle Eastern countries by its milder clinical and aggressive radiologic disease presentation.

Lung volume recruitment in multiple sclerosis.

Risk of multiple sclerosis following clinically isolated syndrome: a 4-year prospective study.
The aim of the study was to estimate the rate of conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) and to investigate variables predicting conversion in a cohort of patients presenting with symptoms suggestive of MS. Patients with a first symptom suggestive of MS in the preceding 6 months and exclusion of other diseases were enrolled in an observational prospective study  from December 2004 through June 2007.

Advances in the treatment of relapsing—remitting multiple sclerosis — critical appraisal of fingolimod

How does fingolimod (gilenya(®)) fit in the treatment algorithm for highly active relapsing-remitting multiple sclerosis?

Adverse events during the titration phase of interferon-beta in remitting-relapsing multiple sclerosis are not predicted by body mass index nor by pharmacodynamic biomarkers

A pragmatic parallel arm multi-centre randomised controlled trial to assess the effectiveness and cost-effectiveness of a group-based fatigue management programme (FACETS) for people with multiple sclerosis.

Teriflunomide in relapsing multiple sclerosis: therapeutic utility.

Magnetic resonance monitoring of lesion evolution in multiple sclerosis.

The effect of fluoxetine on progression in progressive multiple sclerosis: a double-blind, randomized, placebo-controlled trial.

The effect of vitamin a supplementation on biochemical parameters in multiple sclerosis patients.

Updates on clinically isolated syndrome and diagnostic criteria for multiple sclerosis.

Epidemiology in multiple sclerosis: a pilgrim's progress.

[Multiple sclerosis and pregnancy].

Regional cortical thickness in relapsing remitting multiple sclerosis: A multi-center study.

Multicentre absolute myelin water content mapping: Development of a whole brain atlas and application to low-grade multiple sclerosis.

Improving the clinical correlation of multiple sclerosis black hole volume change by paired-scan analysis.

Mimotopic peptide immunotherapy for the treatment of multiple sclerosis, an inflammatory autoimmune disease.

P300 wave changes in patients with multiple sclerosis.

Is There Extra Cost of Institutional Care for MS Patients?

Adding to the burden: gastrointestinal symptoms and syndromes in multiple sclerosis.

Multiple cancers in a patient with systemic sclerosis and aggravated interstitial lung disease by chemotherapy.

Growth hormone response to clonidine administration for evaluation of autonomic dysfunction in multiple sclerosis patients.

Third ventricular enlargement in early stages of multiple sclerosis is a predictor of motor and neuropsychological deficits: a cross-sectional study.

Predictors of effectiveness of multidisciplinary rehabilitation treatment on motor dysfunction in multiple sclerosis.

Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial.

A Randomized, Double-Blind, Placebo-Controlled Trial of Duloxetine for the Treatment of Pain in Patients withMultiple Sclerosis.

Quality of life outcomes with BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: The DEFINE study.

Tolerability and pharmacokinetics of delayed-release dimethyl fumarate administered with and without aspirin in healthy volunteers.

BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety.

Stress in multiple sclerosis: review of new developments and future directions.

Does pain in individuals with multiple sclerosis affect employment? A systematic review and meta-analysis.

Emerging injectable therapies for multiple sclerosis.

Aerobic exercise increases hippocampal volume and improves memory in multiple sclerosis: Preliminary findings.
Changes of brain resting state functional connectivity predict the persistence of cognitive rehabilitation effects in patients with multiple sclerosis.

Effect of textured insoles on balance and gait in people with multiple sclerosis: an exploratory trial.

Inflammation Markers in Multiple Sclerosis: CXCL16 Reflects and May Also Predict Disease Activity.

Increased breast cancer risk for patients with multiple sclerosis: a nationwide population-based cohort study.

Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients.

Measuring response in the gastrointestinal tract in systemic sclerosis.

Natalizumab (tysabri)-associated progressive multifocal leukoencephalopathy: insights from perfusion magnetic resonance imaging.

Placebo-controlled trial of oral laquinimod in multiple sclerosis: MRI evidence of an effect on brain tissue damage.

Disease-activity-free status in patients with relapsing-remitting multiple sclerosis treated with daclizumab high-yield process in the SELECT study.

Neuropsychological rehabilitation has beneficial effects on perceived cognitive deficits in multiple sclerosisduring nine-month follow-up.

The discovery of natalizumab, a potent therapeutic for multiple sclerosis

Immunoregulatory Effects of Interferon-β in Suppression of Th17 cells.

Quantification of multiple-sclerosis-related brain atrophy in two heterogeneous MRI datasets using mixed-effects modeling.

Intra-individual variability in information processing speed reflects white matter microstructure in multiple sclerosis.

Cognition in MS correlates with resting-state oscillatory brain activity: An explorative MEG source-space study.

OASIS is Automated Statistical Inference for Segmentation, with applications to multiple sclerosis lesion segmentation in MRI.

DTI detects water diffusion abnormalities in the thalamus that correlate with an extremity pain episode in a patient with multiple sclerosis.

A comprehensive approach to the segmentation of multichannel three-dimensional MR brain images in multiple sclerosis.

Regional cortical thickness in relapsing remitting multiple sclerosis: A multi-center study.

Multicentre absolute myelin water content mapping: Development of a whole brain atlas and application to low-grade multiple sclerosis.

Improving the clinical correlation of multiple sclerosis black hole volume change by paired-scan analysis.

Mimotopic peptide immunotherapy for the treatment of multiple sclerosis, an inflammatory autoimmune disease.

The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseases.

Relative contribution of cognitive and physical disability components to quality of life in MS.

Improvement of driving skills in persons with Relapsing-Remitting Multiple Sclerosis: a pilot study.

Initial Immunopathogenesis of Multiple Sclerosis: Innate Immune Response.

TNFRSF1A in multiple sclerosis: A tale of soluble receptors and signaling cascades.

Clinically meaningful performance benchmarks in MS: Timed 25-Foot Walk and the real world.

A nine-year population-based cohort study on the risk of multiple sclerosis in patients with optic neuritis.

Mood and coping in clinically isolated syndrome and multiple sclerosis.

Alemtuzumab-Related Thyroid Dysfunction in a Phase 2 Trial of Patients with Relapsing-Remitting Multiple Sclerosis.

A single session of 1 mA anodal tDCS-supported motor training does not improve motor performance in patients with multiple sclerosis.

Regional brain atrophy and functional connectivity changes related to fatigue in multiple sclerosis.

Functional brain network analysis using minimum spanning trees in Multiple Sclerosis: An MEG source-space study.

Fatty fish intake is associated with decreased occurrence of multiple sclerosis.

Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists 

Vowel Acoustics in Parkinson's Disease and Multiple Sclerosis: Comparison of Clear, Loud, and Slow Speaking Conditions

Predictors of effectiveness of multidisciplinary rehabilitation treatment on motor dysfunction in multiple sclerosis.

A Randomized, Double-Blind, Placebo-Controlled Trial of Duloxetine for the Treatment of Pain in Patients with Multiple Sclerosis.

Rare Inflammatory Diseases of the White Matter and Mimics of Multiple Sclerosis and Related Disorders.

Retinal Nerve Fiber Layer Thickness, Brain Atrophy, and Disability in Multiple Sclerosis Patients.

Reduced axonal motor protein expression in non-lesional grey matter in multiple sclerosis

HLA-E restricted CD8+ T cell subsets are phenotypically altered in multiple sclerosis patients 

Automated extraction of clinical traits of multiple sclerosis in electronic medical records

Quality of life outcomes with BG-12 (dimethyl fumarate) in patients with relapsing–remitting multiple sclerosis: The DEFINE study 

Early pathological alterations of lower lumber cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model

The CYP27B1 variant associated with increased risk of autoimmune disease is underexpressed in tolerising dendritic cells.

Intraoperative smile in a multiple sclerosis patient with medication-refractory tremor.