Monday, May 12


Biogen Idec, Elan facing suits over Tysabri side effects-Allegedly failed to warn of risks
On Aug. 28 of last year Kimberley Yout, 45, was diagnosed with a rare brain infection that developed as a side effect of Tysabri, a drug she took for six years to keep her MS in check. Yout’s speech became slurred, her gait unsteady, and her future uncertain. Now, she is suing the two companies that marketed Tysabri — Biogen Idec Inc. of Weston and the Irish drug maker Elan Pharmaceuticals Inc. 
The lawsuit is one of at least a half-dozen pending in Massachusetts and federal courts in three other states. In each case, plaintiffs are seeking more than $1 million in punitive damages from Biogen Idec and Elan on behalf of patients or their families. After taking Tysabri, the patients developed progressive multifocal leukoencephalopathy, known as PML, an infection of the brain’s white matter that can cause death or severe disability. Her complaint, filed Friday, alleges they failed to adequately warn patients of the risks some face from prolonged use of Tysabri.more

 Multiple Sclerosis Appears to Originate in Different Part of Brain ...
News from Rutgers
The search for the cause of multiple sclerosis, a debilitating disease that affects up to a half million people in the United States, has confounded researchers and ...

Does robot-assisted gait training ameliorate gait abnormalities in multiple sclerosis? A pilot randomized-control trial.

Interactions of environment and genes in multiple sclerosis.
MS susceptibility is comprised of both genetic and environmental factors and it has become increasingly clear that these interact. The major histocompatiblity complex is the major site of the interactions which determine MS risk.

Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis
To assess the relationships of sun exposure history, supplementation and environmental factors to vitamin D levels in multiple sclerosis (MS) patients and to evaluate the associations between sun exposure and MRI measures.  Sun exposure may have direct effects on MRI measures of neurodegeneration in MS, independently of vitamin D.

Interferon beta failure predicted by EMA criteria or isolated MRI activity in multiple sclerosis

Application and a proposed modification of the 2010 McDonald criteria for the diagnosis of multiple sclerosis in a Canadian cohort of patients with clinically isolated syndromes 

The interface between neurology and psychiatry: the case of multiple sclerosis

Hunting for autoantibodies in multiple sclerosis

Migraine prevalence, socioeconomic status, and social causation
To determine whether the known higher prevalence of migraine in lower household (HH) income groups is explained by a higher incidence rate or a lower remission rate.  The higher incidence of migraine in lower HH income groups is compatible with the social causation hypothesis.

Severe Disability in Patients with Relapsing-Remitting Multiple Sclerosis Is Associated with Profound Changes in the Regulation of Leptin Secretion..

Randomized controlled trial of a behavioral intervention targeting symptoms and physical activity in multiple sclerosis.

Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosi

Neuroborreliosis during Tysabri (natalizumab) treatment in multiple sclerosis
We present a case of acute neuroborreliosis in the setting of long-term treatment with natalizumab. A 33-year-old man was diagnosed with relapsing-remitting multiple sclerosis (MS) in 1999.

Bank assists Staten Island's Multiple Sclerosis Group