Monday, May 12


Half of new MS patients may soon get Biogen’s Tecfidera
Boston-based financial services group Cowen Group Inc. said Friday morning that based on patient data, Biogen Idec Inc.’s new drug, Tecfidera, may soon be getting more than half of all new multiple sclerosis patients. The Weston, Mass. biotech launched Tecfidera in March and has managed to outdo already-high expectations ever since. During its first three months on the market, the drug accounted for more than 10 percent of the Weston, Mass.-based drug company’s second-quarter revenues of $1.7 billion, which was up 21 percent year-over-year.

Therapeutic potential of cannabinoid medicines.
Cannabis was extensively used as a medicine throughout the developed world in the nineteenth century but went into decline early in the twentieth century ahead of its emergence as the most widely used illicit recreational drug later that century. This paper will then go on to review clinical research exploring the potential of cannabinoid medicines in the following indications: symptomatic relief in multiple sclerosis, chronic neuropathic pain, intractable nausea and vomiting, loss of appetite and weight in the context of cancer or AIDS, psychosis, epilepsy, addiction, and metabolic disorders.

Post-Tysabri (natalizumab) clinical and radiological findings in a cohort of multiple sclerosis patients: 12-month follow-up.
There is an urgent need to identify the best strategies to prevent the loss of natalizumab (N) beneficial effects after its suspension. The objective is to evaluate the clinical and radiological disease activity and to test the efficacy of immunomodulatory/immunosuppressive drugs (IT) after N suspension.

Quality of life and employment in persons with multiple sclerosis.
Results of the study emphasize the need for the provision of quality vocational services to persons with MS. Issues such as quality vocational services, timeliness, and the importance of continued work are discussed.

The experience of being grounded: a phenomenological study of living with a wheelchair.
The purpose of this existential-phenomenological study was to investigate the experience of being in a wheelchair. It was a prelude to a pilot study examining the effect of "seated" Tai Chi.  The accommodations from the ADA Act have greatly facilitated the independence for those who are disabled, yet many obstacles remain.

 Epstein-Barr virus in oral shedding of children with multiple sclerosis

Notre Dame Men's Tennis Set To Host "Smash MS" Clinic Saturday

Evaluation of an electronic diary for improvement of adherence to interferon beta-1b in patients with multiple sclerosis: design and baseline results of an observational cohort study

Tour de South Shore ride to benefit Alzheiemer's, MS research

Monoclonal antibodies in targeted therapy.

What sample sizes for reliability and validity studies in neurology?

Improved operator agreement and efficiency using the minimum area contour change method for delineation of hyperintense multiple sclerosis lesions on FLAIR MRI.

A Novel pH-Sensitive Interferon-β (INF-β) Oral Delivery System for Application in Multiple Sclerosis.

Neuromyelitis optica: atipic clinic presentation.

Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development.

Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica.
Impairment of JCV-specific T-cell response by corticotherapy: effect on PML-IRIS management?
Matrix metalloproteinases and their pathological upregulation in multiple sclerosis: an overview.

Meta-Analysis of the Correlation Between Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis.
To determine whether a correlation exists between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS).

Cognitive functions in multiple sclerosis: impact of gray matter integrity.
Our aim was to investigate the impact of gray matter (GM) integrity on cognitive performance in multiple sclerosis (MS), and its relationship with white matter (WM) integrity and presence of lesions.  GM and WM integrity of specific networks influences cognitive performance in MS. However, GM damage assessed by DTI only adds a small increment to the explained variance by WM in predicting cognitive functioning.

(CCVI) Chronic cerebrospinal venous insufficiency--pathophysiology and treament
Multiple sclerosis (sclerosis multiplex--SM) is a chronic nervous sytem disease, which through formation of demyenilisation focus in the central nervous system leads to deterioration of its various functions. In the consequence it may cause invalidity of patient.