Monday, May 12


Tysabri (Natalizumab) affects the T-cell receptor repertoire in patients with
multiple sclerosis

   Clemens Warnke, Anne K. Mausberg, Mark Stettner, Thomas Dehmel, Lina
   Nekrich, Gerd Meyer zu Horste, Hans-Peter Hartung, Anna Fogdell-Hahn,
   Ortwin Adams, and Bernd C. Kieseier
   Neurology. published 18 September 2013, 10.1212/WNL.0b013e3182a84101

Risk factors related to cardiovascular diseases and the metabolic syndrome
in multiple sclerosis - a systematic review

   Inez Wens, Ulrik Dalgas, Egon Stenager, and Bert O. Eijnde
   Multiple Sclerosis Journal. published 18 September 2013,

Moving towards the pan-European unification of Multiple Sclerosis Nurses: a
consensus paper

   N Ward-Abel, W Kohler, V Matthews, M Messmer Uccelli, C Mouzawak, A
   Perrin Ross, L Pyciakova, A Winslow, and J Kraus
   Multiple Sclerosis Journal. published 18 September 2013,

Higher Relative Risk for Multiple Sclerosis in a Pediatric and Adolescent Diabetes Population: Analysis From DPV Data Base.
Department of Pediatrics, Medical University Munich, Germany: Bechtold S, Blaschek A, Raile K, Dost A, Freiberg C, Askenas M, Fröhlich-Reiterer E, Molz E, Holl RW.
Diabetes Care. 2013 Aug 29. [Epub ahead of print]

On August 22, 2013, co-hosts Brad Culp and Sam Grass of Business RadioX®'s Eugeria! Radio™ discussed the invisible side of MS and previewed Griswold Home Care's On-Line Training for Caregivers, Social Workers, Nurses and Administrators.

The multiple sclerosis relapse experience: patient-reported outcomes from the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry.
Nickerson M, Marrie R A
BMC Neurol. 2013 Sep 10; 13(1):119. PMID: 24016260.
Overall, patients with relapsing multiple sclerosis who receive treatment report better outcomes than those who are simply observed. However, a sizeable percentage of patients feel that their symptoms following corticosteroid treatment are worse than pre-relapse symptoms and that treatment had no effect or worsened symptoms. Patient perceptions of relapse treatment deserve more attention, and more effective treatment options are needed.

Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica.
Department of Neurology, Tokyo Women's Medical University, School of Medicine: Tokyo, Japan. Shimizu Y, Ota K, Ikeguchi R, Kubo S, Kabasawa C, Uchiyama S.
J Neuroimmunol. 2013 Jul 30. pii: S0165-5728(13)00178-1. doi: 10.1016/j.jneuroim.2013.07.005. [Epub ahead of print]

Which immune cells matter? The immunopathogenesis of multiple sclerosis.
Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is believed to be immune-mediated. While CD4+ T cells have been the main suspects for years, there is ample evidence that other immune cells (including those of the innate immune system) play a contributing or regulating role in this disease. After a general introduction, this review focuses on different immune cell subsets implicated in MS pathogenesis and on current and future possibilities to target them for therapeutic use.unknown.

2010 McDonald criteria in a pediatric cohort: is positivity at onset associated with a more aggressive multiple sclerosis course?
The 2010 McDonald criteria allow the diagnosis of multiple sclerosis (MS) at first attack in children and adults provided that the first attack symptoms are typical of MS and that the magnetic resonance imaging (MRI) conforms to prescribed features.

Gene expression changes underlying cortical pathology: clues to understanding neurological disability in multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with an unknown etiology.

Apitope Announces Positive Results from Clinical Trial of ATX-MS-1467 in Relapsing Multiple Sclerosis 

Leisure Fitness Supports the Bike MS: Bike to the Bay, 9/21
Leisure Fitness is proudly supporting the Bike MS: Bike to the Bay on September 21st, 2013 to benefit the National Multiple Sclerosis Society. The team will be taking the road at 1pm at Uncle Ted's Rest Stop in Milton, DE and riding the 17 miles to the finish line.  
Cytomegalovirus seropositivity is negatively associated with multiple sclerosis.
Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk.  CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk.

Multiple sclerosis: RBPJ identified as an autoantigen in multiple sclerosis.

Evaluation of WO2013076170: the use of a dihydroorotate dehydrogenase inhibitor for the treatment of psoriasis.
Inhibition of dihydroorotate dehydrogenase (DHODH) modulates pyrimidine biosynthesis. Effective inhibitors are immunomodulatory drugs clinically useful in the treatment of diseases such as rheumatoid arthritis, psoriatic arthritis and multiple sclerosis.

Oral BG-12 (dimethyl fumarate) for relapsing-remitting multiple sclerosis: a review of DEFINE and CONFIRM Evaluation of: Gold R, Kappos L, Arnold D, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 2012;367:1098-107; and Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med 2012;367:1087-97.
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease of the central nervous system involving inflammation, chronic demyelination and axonal loss.

A case of hereditary diffuse leukoencephalopathy with axonal spheroids caused by a de novo mutation in CSF1R masquerading as primary progressive multiple sclerosis
We report a sporadic case of hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) confirmed by biopsy and colony-stimulating factor 1 receptor (CSF1R) sequencing.

Epidemiology and clinical record of multiple sclerosis in selected countries - a systematic review.
Abstract Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system mainly affecting young adults.

Polymerase I pathway inhibitor ameliorates experimental autoimmune encephalomyelitis.
Applying high throughput gene expression microarrays we identified that the suppression of polymerase 1 (POL1) pathway is associated with benign course of multiple sclerosis (MS).