Monday, May 12


 Contribution of cortical and white matter lesions to cognitive impairment in multiple sclerosis

Symptom overlap in anxiety and multiple sclerosis

Cerebral white matter blood flow and energy metabolism in multiple sclerosis

Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation

Assessing interactions between HLA-DRB1*15 and infectious mononucleosis on the risk of multiple sclerosis

Perceived and actual arm performance in multiple sclerosis: relationship with clinical tests according to hand dominance

Retinal nerve fiber layer thickness in benign multiple sclerosis

International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system

Pediatric onset multiple sclerosis: McDonald criteria 2010 and the contribution of spinal cord MRI

Application of the McDonald 2010 criteria for the diagnosis of multiple sclerosis in an Argentinean cohort of patients with clinically isolated syndromes

Childhood body mass index and multiple sclerosis risk: a long-term cohort study
High risk of cardiovascular diseases after diagnosis of multiple sclerosis

Brain Changes May Explain Stroke Risk In Migraine Sufferers

Some people who get migraines do have a slightly higher risk of stroke. And some of the brain changes identified in the study look like mini strokes. "On the MRI migraines look like very tiny strokes," Lipton tells Shots. But the people aren't having any stroke symptoms. Still, Lipton is convinced that the process is the same. "We now know it's a risk factor for these very small silent strokes," 

Migraine and structural changes in the brain: A systematic review and meta-analysis

Migraine prevalence, socioeconomic status, and social causation

Sunbathing more effective than vitamin D in preventing multiple sclerosis
A little ray of sunshine can help combat fatigue and depression and decrease the risk of multiple sclerosis, according to new findings. GETTING a regular dose of sunshine is much more effective than vitamin D at combating fatigue and depression. STUDY: Participants also reported on the length of time they spent sunbathing. It emerged that those who spent longer in the sun suffered less from fatigue and depression.

MS study targets damage affecting nerves
Dr Veronique Miron, MRC for Regenerative Medicine at the University of Edinburgh, explains that "In multiple sclerosis patients, the protective layer surrounding ..

A guide to facilitate the early treatment of patients with idiopathic demyelinating disease (multiple sclerosis and neuromyelitis optica)

2010 McDonald criteria in a pediatric cohort: is positivity at onset associated with a more aggressive multiple sclerosis course?

A case of hereditary diffuse leukoencephalopathy with axonal spheroids caused by a de novo mutation in CSF1R masquerading as primary progressive multiple sclerosis

Gene expression changes underlying cortical pathology: clues to understanding neurological disability in multiple sclerosis
Higher Relative Risk for Multiple Sclerosis in a Pediatric and Adolescent Diabetes Population: Analysis From DPV Data Base

Indian Ranch to Host Concert To Benefit CFMS Foundation

Assessment of the influence of rehabilitation in patients treated in a hospital rehabilitation ward due to consequences of neurological diseases

Epidemiology in multiple sclerosis: a pilgrim's progress.

Dr. Jill Conway
The cost of medication and the cost of treatment are not the same thing for multiple sclerosis.

Charlotte doctor commits her career to treating multiple sclerosis
Dr. Jill Conway, director of the Multiple Sclerosis Cenjter at Carolinas Medical Center, enjoys working in a field with so many medical advances and one that ...

Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial.

European Commission Approves Genzyme's Once-Daily, Oral Aubagio...
Wall Street Journal

Review series on immune responses in neurodegenerative diseases: Oligodendrocyte-microglia cross-talk in the CNS.

Predictors of executive complaints and executive deficits in multiple sclerosis.
Among the study variables, depression was the strongest predictor of executive complaints. A high degree of neurological disability was the strongest predictor for executive deficit, measured by neuropsychological tests.

A comparison of sagittal short T1 inversion recovery and T2-weighted FSE sequences for detection of multiple sclerosis spinal cord lesions.
Multiple sclerosis (MS) is the most common disabling CNS disease of young adults.  Short T1 inversion recovery sequence imaging not only significantly improves detection of MS lesions within the spinal cord, but also provides better contrast and conspicuity of visible lesions, creating a more confident diagnostic measure of MS extent and progression. Short T1 inversion recovery sequences of the spinal cord should be routinely obtained during initial and routine follow-up of MS.

Changes in expression of the antioxidant enzyme SOD3 occur upon differentiation of human bone marrow-derived mesenchymal stem cells in vitro.

A standardized motor imagery introduction program (MIIP) for neuro-rehabilitation: development and evaluation.

The quality of primary health care for chronically ill patients: a cross-sectional study.
The areas that the participants gave the highest ratings to are subjective and objective examinations, kindness and willingness to help. The strongest correlations between high assessments of the quality of care provided for chronically ill patients at primary care clinics were observed in the following variables: gender, age, level of education, frequency of visits, therapy conducted by a doctor at a specialist clinic, arterial hypertension, COPD and/or myocardial infarction.

Pathophysiology of the brain extracellular matrix: a new target for remyelination.

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis.

Endogenous retroviruses and multiple sclerosis--new pieces to the puzzle.

Assessment of the influence of rehabilitation in patients treated in a hospital rehabilitation ward due to consequences of neurological diseases.

Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications.

Survival and predictors of mortality in systemic sclerosis associated pulmonary arterial hypertension: Outcomes from the PHAROS registry.

Obama administration will not block state marijuana laws, if distribution is regulated - The Washington Post
he Obama administration said Thursday that it would not challenge laws legalizing marijuana in Colorado and Washington State as long as those states maintain strict rules involving the sale and distribution of the drug.
In a memo to US Attorneys in all 50 States, Deputy Attorney General James M. Cole said the Justice Department is “committed to using its limited investigative and prosecutorial resources to address the most significant threats in the most effective, consistent and rational way.” He stressed that marijuana remains illegal under federal law.

The effect of Prozac (fluoxetine) on progression in progressive multiple sclerosis: a double-blind, randomized, placebo-controlled trial.
ISRN Neurol. 2013 Jul 29;2013:370943. doi: 10.1155/2013/370943.
Department of Neurology, University Medical Center Groningen, University of Groningen, Postbus 30.001, 9700 RB Groningen, The Netherlands ; Department of Neurology, Rijnstate Hospital, Postbus 9555, 6800 TA Arnhem, The Netherlands.

Medication withdrawal may be an option for a select group of patients in relapsing-remitting multiple sclerosis.
This article describes the clinical and radiological evolution of a stable group of patients with relapsing-remitting multiple sclerosis that had their disease-modifying therapy (DMT) withdrawn. Withdrawal, however, should not be viewed as simply the suspension of treatment because these patients should be evaluated periodically, and the immunomodulators should be readily reintroduced if new attacks occur. Nonetheless, medication withdrawal is an option for a select group of patients.

Antiparasitic antibodies occur with similar frequency in patients with clinically established multiple sclerosis with or without oligoclonal bands in the cerebrospinal fluid.

Updates on clinically isolated syndrome and diagnostic criteria for multiple sclerosis.
Department of Neurology, University of California, San Francisco, CA, USA.
Clinically isolated syndrome (CIS) is a central nervous system demyelinating event isolated in time that is compatible with the possible future development of multiple sclerosis (MS). Early risk stratification for conversion to MS helps with treatment decisions. Magnetic resonance imaging (MRI) is currently the most useful tool to evaluate risk.

Walking execution is not affected by divided attention in patients with multiple sclerosis with no disability, but there is a motor planning impairment.
Conclusion: MS patients with no disability did not show any influence of divided attention on walking execution. However, motor planning was overestimated as compared with real walking.

MicroRNAs as Novel Regulators of Neuroinflammation.

The effect of vitamin a supplementation on biochemical parameters in multiple sclerosis patients.

A&W's Cruisin' for a Cause Raises $5 Million Over 5 Years
Wall Street Journal: Cruisin' for a Cause (or le Rendez-vous A&W pour stopper la SP as it is known in Quebec) raised both funds and awareness of multiple sclerosis through a ...

In systemic sclerosis, anxiety and depression assessed by hospital anxiety depression scale are independently associated with disability and psychological factors.
Biomed Res Int. 2013;2013:507493. doi: 10.1155/2013/507493. Epub 2013 Jul 29.

Therapeutic Effect of Transplanted Human Wharton's Jelly Stem Cell-Derived Oligodendrocyte Progenitor Cells (hWJ-MSC-derived OPCs) in an Animal Model of Multiple Sclerosis.

Now this will Mekk you feel better!
The Samson Centre is the home of The Multiple Sclerosis Therapy Group in Guildford and is a small self-funded charity that provides physiotherapy and oxygen ...

Coping with a New Multiple Sclerosis Diagnosis
Huffington Post Canada: In her weekly column, Natalie answers your questions about caring for a family member or friend who needs extra support -- and caring for yourself as a ...

Band performs for MS
The Band of Her Majesty's Royal Marines Plymouth will perform a one-off fundraising concert for Multiple Sclerosis Auckland in September.

There is much to be learnt about the costs of multiple sclerosis in Latin America.

Multiple sclerosis is primarily a neurodegenerative disease.

Dr. Bill Code, M.D. to Present on Integrative Therapies for Brain Recovery in Multiple Sclerosis

Nutra Pharma Announces Delivery of Nyloxin(tm) to New Vitality
... biotechnology company that is developing treatments for Multiple Sclerosis (MS), Human Immunodeficiency Virus (HIV), Adrenomyeloneuropathy (AMN) and ...

FDA Warns of PML Case With Gilenya
MedPage Today: A patient being treated for multiple sclerosis and who had no history of using natalizumab (Tysabri) developed progressive multifocal ...

Home-based exercise program and fall-risk reduction in older adults with multiple sclerosis: phase 1 randomized controlled trial.

Sex-specific extent and severity of white matter damage in multiple sclerosis: Implications for cognitive decline.

Tecfidera’s Patient Share at Three Months Postlaunch Surpasses That for Aubagio and Gilenya At the Same Stage of Their Launches
Over the next six months, Tecfidera's patient share among DMT-treated RR-MS patients is anticipated to increase significantly to 16 percent. In fact, despite being the third oral DMT to reach the MS market, patient share for Tecfidera exceeds that for the first two oral DMTs for MS—Sanofi/Genzyme’s Aubagio (1 percent) and Novartis’s Gilenya (1 percent)—at the same stage of their respective launches. Current physician trial rate for Tecfidera (65 percent) beats that for Aubagio (33 percent) and Gilenya (53 percent).

Salt-Heavy Diets Can Lead to Autoimmune Diseases
Men's Journal
These ailments, which include multiple sclerosis, type 1 diabetes, inflammatory bowel disease, and psoriasis, result from an immune system gone haywire that ...

Prescription-Drug Coupons — No Such Thing as a Free Lunch
Visit nearly any official website for a brand-name drug available in the United States and, mixed in with links to prescribing and safety information, you'll find links to drug “coupons,” including copayment-assistance programs and monthly savings cards. Most offers are variations on “Why pay more? With the [drug] savings card, you can get [drug] for only $18 per prescription if eligible” or “Get a free 30-capsule trial of [drug] with your doctor's prescription and ask your doctor if [drug] is right for you.” Why do manufacturers offer drug coupons? Are they good for patients in the long run? Are they even legal?

Endogenous retroviruses and multiple sclerosis--new pieces to the puzzle
7thSpace Interactive (press release)
The possibility that retroviruses play a role in multiple sclerosis (MS) has long been considered; accumulating findings suggest this to be most likely in the form of ...

How Will the Obamacare Out-of-Pocket Cap Delay Affect MS Patients?
For people with multiple sclerosis (MS) who must often pay high co-payments for health services and prescription drugs, this news comes as a crushing blow.

Opexa Therapeutics Inc awarded 50th patent for T-cell immunotherapy platform for multiple sclerosis
Aug 28, 2013 (Menafn - M2 EQUITYBITES via COMTEX) --Biotechnology company Opexa Therapeutics Inc (nasdaqcm:OPXA) reported on Tuesday the receipt ...

Atos Tests Branded 'Farcical' After Finding Multiple Sclerosis ...
Huffington Post UK
The study looked at people with cystic fibrosis, multiple sclerosis, Parkinson's or rheumatoid arthritis who applied for Employment Support Allowance between ...

Big Sunfest cheques thrill MS societies
Both the Cowichan Exhibition Society and the Cowichan Valley chapter of the Multiple Sclerosis Society were the happy recipients of big cheques Thursday, ..

Non-myeloablative autologous haematopoietic stem cell transplantation
expands regulatory cells and depletes IL-17 producing mucosal-associated
invariant T cells in multiple sclerosis

Magnetic resonance monitoring of lesion evolution in multiple sclerosis
 Specific aspects of modern life for people with multiple sclerosis: considerations for the practitioner  

Community: Sept. 21 event to benefit MS program
Corvallis Gazette Times
The runs will benefit Oregon State's Multiple Sclerosis Exercise Program, which helps people with multiple sclerosis. Participants in the program receive free ...

Neurostimulators for the Treatment of Primary Headaches
Response rates reported in neurostimulation studies do not seem superior to those of the most effective prophylactic medications. Selection criteria for neurostimulation in headache patients are not uniform, and with few exceptions follow-up is too short to provide firm conclusions on long-term efficacy and safety, as well as costs. Notwithstanding these limitations, occipital nerve stimulation does seem to produce satisfactory improvement in chronic drug-resistant cluster headache and when it does not produce benefit, hypothalamic stimulation can be considered. Occipital nerve stimulation has been extensively investigated as a treatment of chronic migraine, but there is still some skepticism about its efficacy.[88]

Signs and symptoms of Multiple Sclerosis
Palm Beach Post
It is estimated that more than 2.1 million people worldwide are affected by multiple sclerosis (MS). Multiple sclerosis is a chronic, often disabling disease that ...

Atos Tests Branded 'Farcical' After Finding Multiple Sclerosis ...
Huffington Post UK
People with crippling illnesses like cystic fibrosis and multiple sclerosis are being found fit for ... The study looked at people with multiple sclerosis, Parkinson's or ...

 Specific aspects of modern life for people with multiple sclerosis: considerations for the practitioner
   Celia Oreja-Guevara, Heinz Wiendl, Bernd C. Kieseier, and Laura Airas
   Therapeutic Advances in Neurological Disorders. published 27 August
   2013, 10.1177/1756285613501575

Natural killer cells and their receptors in multiple sclerosis
   Gurman Kaur, John Trowsdale, and Lars Fugger
   Brain. 2013;  136(9): p. 2657-2676

T-cell homeostasis in pediatric multiple sclerosis: Old cells in young patients
   Bettina Balint, Jurgen Haas, Alexander Schwarz, Sven Jarius, Alexandra
   Furwentsches, Kathrin Engelhardt, Cornelia Bussmann, Friedrich Ebinger,
   Benedikt Fritzsching, Friedemann Paul, Ulrich Seidel, Stefan Vlaho,
   Peter Huppke, Jutta Gartner, and Brigitte Wildemann
   Neurology. 2013;  81(9): p. 784-792

Epidemiology in multiple sclerosis: a pilgrim's progress
   John F. Kurtzke
   Brain. 2013;  136(9): p. 2904-2917

Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis
   Sofia V. Abrahamsson, Daniela F. Angelini, Amy N. Dubinsky, Esther
   Morel, Unsong Oh, Joanne L. Jones, Daniele Carassiti, Richard Reynolds,
   Marco Salvetti, Peter A. Calabresi, Alasdair J. Coles, Luca Battistini,
   Roland Martin, Richard K. Burt, and Paolo A. Muraro
   Brain. 2013;  136(9): p. 2888-2903

Magnetic resonance monitoring of lesion evolution in multiple sclerosis
   Alex Rovira, Cristina Auger, and Juli Alonso
   Therapeutic Advances in Neurological Disorders. 2013;  6(5): p. 298-310

The Multiple Sclerosis Association of America Launches New ...
Sacramento Bee
CHERRY HILL, N.J., Aug. 27, 2013 -- /PRNewswire/ -- The Multiple Sclerosis Association of America (MSAA) is pleased to announce new website additions ...

Dresher Jeweler Holding Multiple Sclerosis Fundraiser
28, Lester Martin Jewelers, at 1650 Limekiln Pike in Dresher, will donate a portion of their proceeds to the Multiple Sclerosis Society of Greater Philadelphia.

Sobell changing gears on fundraiser
Lompoc Record
All money raised will be donated to the National Multiple Sclerosis Society. Registration fee is $50 and includes the run/ride, rest stops, support and gear and the ...

 Use of a biomarker in exposure-response analysis to support dose selection for fingolimod.

Patient-related factors may affect the outcome of neuropsychological rehabilitation in multiple sclerosis.
Patient-related factors affected rehabilitation outcome, whereas illness- and intervention-related factors did not. The results showed that especially MS patients with male gender and more severe attentional deficits benefitted from the intervention (attention retraining, teaching compensatory strategies, psychoeducation, psychological support, and homework assignments).

Anti-JCV antibody prevalence in a French cohort of MS patients under natalizumab therapy.

Prolonged and symptomatic bradycardia following a single dose of GILENYA

CLINICAL TRIAL: Investigators Recruiting For Study of Lower Dose of Gilenya Versus Copaxone In MS

 Information on Current and Completed Pregnancy Registries for MS Therapies

(VIDEO) A Summer Spent At MS Center Offers Insight Into Mom's Battle

T-cell homeostasis in pediatric multiple sclerosis: Old cells in young patients

Premature immune senescence in children with MS: Too young to go steady

Glatiramer acetate–induced acute hepatotoxicity in an adolescent with MS

Cerebrospinal fluid derived immunoglobulin G of different multiple sclerosis patients share mutated sequences in complementarity determining regions.

The impact of diagnostic criteria for neuromyelitis optica in patients with MS: a 10-year follow-up of the South Atlantic Project.

Application and a proposed modification of the 2010 McDonald criteria for the diagnosis of multiple sclerosis in a Canadian cohort of patients with clinically isolated syndromes.

Paroxysmal ataxia and dysarthria in multiple sclerosis.

Evidence against the Involvement of Chronic Cerebrospinal Venous Abnormalities in Multiple Sclerosis. A Case-Control Study.

Clinical and MRI activity as determinants of sample size for pediatric multiple sclerosis trials.

Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis.

Health plan utilization and costs of specialty drugs within Multiple Sclerosis

Depression: Can a Coach Help?
Adding old-fashioned technology -- the telephone -- to a Web-based intervention for depression improved adherence to the intervention, but there was no symptom benefit. Compared with those who did not receive telephone coaching to help navigate the depression treatment software, coached patients had significantly more login days (P=0.01) and were likely to continue to use the software for longer periods according to David Mohr, PhD, of Northwestern University Feinberg School of Medicine in Chicago, Ill.,

Pilates for people with multiple sclerosis who use a wheelchair: feasibility, efficacy and participant experiences.
Pilates appears to be efficacious in improving sitting stability and posture and decreasing pain and was also well tolerated by wheelchair users with MS. Further mixed methods studies are warranted. Implications for Rehabilitation Group-based core stability exercise or Pilates for people with MS who use wheelchair is a feasible and safe way of exercising for this patient group. Pilates exercises for people moderately to severely affected by MS resulted in a decrease in back and shoulder pain and improvement in sitting balance. Future appropriately powered randomised controlled studies into Pilates for people with MS reliant on wheelchair are warranted.

AUBAGIO (Teriflunomide) in relapsing multiple sclerosis: therapeutic utility
Therapeutic Advances in Chronic Dis

Surgery and Risk for Multiple Sclerosis: A Systematic Review and Meta-analysis of Case-Control Studies

Abstract-Background: Although the precise etiology of multiple sclerosis is largely unknown, there is some speculation that a prior history of surgery may be associated with the subsequent risk for developing the disease. Therefore, we aimed to examine surgery as a risk factor for the diagnosis of multiple sclerosis.
ease. 2013

The effects of pilates on balance, mobility and strength in patients with multiple sclerosis. NeuroRehabilitation. 2013  [Epub ahead of print]

Seizure Disorders Enter Medical Marijuana Debate

Evaluation of plaque detection and optimum time of enhancement in acute attack multiple sclerosis after contrast injection

Parasite Infections in Multiple Sclerosis Modulate Immune Responses through a Retinoic Acid-Dependent Pathway

Clinic speak: an holistic approach to MS version 3.1

Concomitant amyotrophic lateral sclerosis and paraclinical laboratory features of multiple sclerosis: coincidence or causal relationship?

Relapsing-remitting multiple sclerosis and chronic idiopathic neutropenia: a challenging combination