Sunday, March 15

Markers of JC virus infection in patients with multiple sclerosis under Tysabri (natalizumab) therapy


Presence of anti-JCPyV antibodies and JCPyV DNA was analyzed in 39 patients with relapsing-remitting multiple sclerosis undergoing natalizumab therapy.
Anti-JCPyV antibodies were evaluated in serum by a 2-step virus-like particle-based ELISA assay (Stratify), and JCPyV DNA was evaluated in peripheral blood mononuclear cells, plasma, and urine by quantitative PCR.
The anti-JCPyV antibodies were evaluated in serum samples collected at the same time or later than those collected for DNA analysis.


JCPyV DNA was detected in 59% of patients, and anti-JCPyV antibodies were present in 67%.

JCPyV DNA occurred more often in blood than in urine.

Anti-JCPyV antibodies were observed in 70% of the JCPyV-infected patients, and JCPyV DNA was detected in 50% of the patients without anti-JCPyV antibodies.

When JCPyV DNA was investigated in blood and urine the frequency of infection was higher than previously described.

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