Multiple sclerosis drug brings lethal risks, but great promise for someBy John Fauber
Milwaukee Journal Sentinel
MILWAUKEE - Eric Schmitt munches on a roast beef sandwich as an IV hooked up to his arm drips a precious but potentially lethal fluid into his vein.
Schmitt, 35, knows there is a slight chance the new drug might kill him, but without it his multiple sclerosis could flare up, bringing back the lack of feeling in his lower body, vision problems and difficulty walking.
"I didn't have much choice," he says.
Krista Chapman wakes up worried at 3 a.m. on the day of her first treatment.
After a horrible year of MS relapses in 2006, she reckons that the same drug, Tysabri, will reduce the odds of another setback from which she might not recover, sparing her from disorienting vertigo and overpowering fatigue.
But it also could cause a fatal viral infection in her brain. And at 37, she is too young to die, even though the odds of that seem slim.
As the drug, which costs several thousand dollars a month, slowly is infused into the back of her hand, she seems relaxed sitting up in her hospital bed.
For Schmitt and Chapman as well as an untold number of other MS patients, Tysabri has created a dilemma found with few other medications that treat disabling, but rarely fatal, diseases such as MS...[MORE].
Showing posts with label Tysabri (natalizumab). Show all posts
Showing posts with label Tysabri (natalizumab). Show all posts
Monday, May 5
Subscribe to our FREE email newsletter with any future breaking news about Copaxone, Rebif, Avonex, Novatone, Tysabri, Betaseron...PLUS the 18 new drugs in the pipeline...listed below!
CLICK HERE! Subscribe to our FREE email newsletter
PLUS... YOU'LL RECEIVE SPECIAL ALERTS NOTIFYING YOU OF ANY NEW NEWS ON THESE 16 NEW MS TREATMENTS THAT ARE IN THE PIPLINE:
1...CAMPATH
2...TOVAXIN
3...ORAL FINGOLIMOD - FTY720
4...COPAXONE WITH MITOXANTRONE
5...ORAL LAQUINIMODE BY TEVA
6...ORAL FAMPRIDINE-SR BY SERONO
7...REBIF: NEW FORMULATION
8...ORAL CDP323: Biogen Idec:
9...SATIVEX - CANNABINOID-BASED DRUG
10...MBP8298
11...NICOTINAMIDE: "Daily Nicotinamide Shots
12...NEURODUR.
13...LYRICA: Pfizer's Lyrica(Pregabalin Capsules)
14...SYMADEX
15...Testosterone gel
16...Two CNS Oral Spray Drug Candidates: NovaDel
CLICK HERE! Subscribe to our FREE email newsletter
Headlines on all of 16 treatments listed above...are below or in our Archives from the last few months:
CLICK HERE! Subscribe to our FREE email newsletter
PLUS... YOU'LL RECEIVE SPECIAL ALERTS NOTIFYING YOU OF ANY NEW NEWS ON THESE 16 NEW MS TREATMENTS THAT ARE IN THE PIPLINE:
1...CAMPATH
2...TOVAXIN
3...ORAL FINGOLIMOD - FTY720
4...COPAXONE WITH MITOXANTRONE
5...ORAL LAQUINIMODE BY TEVA
6...ORAL FAMPRIDINE-SR BY SERONO
7...REBIF: NEW FORMULATION
8...ORAL CDP323: Biogen Idec:
9...SATIVEX - CANNABINOID-BASED DRUG
10...MBP8298
11...NICOTINAMIDE: "Daily Nicotinamide Shots
12...NEURODUR.
13...LYRICA: Pfizer's Lyrica(Pregabalin Capsules)
14...SYMADEX
15...Testosterone gel
16...Two CNS Oral Spray Drug Candidates: NovaDel
CLICK HERE! Subscribe to our FREE email newsletter
Headlines on all of 16 treatments listed above...are below or in our Archives from the last few months:
2006 - A Very Good Year in MS Research
During 2006, rapid research progress
was made in the fields of science and medicine that impact understanding
and treatment of multiple sclerosis, an unpredictable neurological disease.
Significant advances have been made in both clinical and laboratory
studies in MS. In addition, more than 130 clinical trials are underway
around the world, and still other experimental drugs are in the pipeline.
Key highlights of the year include:
* Acorda Therapeutics (Hawthorne, NY) announced positive results of a
Phase 3, placebo-controlled clinical trial of Fampridine-SR, an oral
drug designed to provide symptomatic relief by compensating for lost
nerve conduction. In 301 patients with all types of MS, those on active
treatment showed an average increase in walking speed of 25% versus
those on inactive placebo. The company is expected to meet with the
U.S. Food and Drug Administration (FDA) to determine next steps needed
to apply for marketing approval.
* The FDA approved the return to market of Tysabri(R) (natalizumab,
produced by Biogen Idec and Elan Pharmaceuticals) to delay the
accumulation of physical disability and reduce the frequency of relapses
(clinical exacerbations) in those with relapsing MS. There is now in
place a mandatory registration program for patients and prescribing
physicians to minimize the risk of PML (progressive multifocal
leukoencephalopathy), caused by a common virus called the JC virus. The
drug is dispensed at registered infusion centers across the country.
Since Tysabri's return to market last summer, there have been no new
cases of PML reported.
* Members of the four Nervous System Repair teams from Europe and the U.S.
met to share progress being made in the Society funded Promise: 2010
initiative. The first clinical trials focused on protecting the nervous
system will begin shortly, and trials aimed at repairing damage and
restoring function in people with MS are expected to begin within the
next five years.
* In a first, Johns Hopkins University researchers reported that nerve
cells derived from mouse embryonic stem cells that were transplanted
into rats with spinal cord injury were able to connect with muscles and
partially restore function. While this work was done in a model of
spinal cord injury, it bears relevance to the potential use of cell
replacement to repair damage in MS.
* The Society will be sponsoring the first ever stem cell summit January
16-19 in San Francisco to explore the potential of the complete spectrum
of stem cell options as they might relate to MS research and treatment.
The by-invitation only meeting will bring together some 60 renowned
scientists from around the world to examine stem cell prospects and
strategies in MS. The results of this meeting are expected to set
research directions and priorities to best determine the potential of
all types of stem cells for treating this disease.
* Researchers from the University of California, Los Angeles reported that
administering Androgel(R) (testosterone gel applied to the skin) to 10
men with relapsing-remitting MS significantly improved cognitive
function and slowed brain tissue loss. This study was funded by the
Society's initiative on Gender Differences in MS and is expected to lead
to additional research involving larger numbers of patients to confirm
these early results.
* In another offshoot from the Society's initiative on Gender Differences,
UCLA investigators began the first large-scale trial of a sex hormone
for the treatment of MS. The two-year, controlled clinical trial of
estriol involves 130 women with early relapsing-remitting MS. If
successful, this clinical trial will lay the groundwork for a larger,
definitive trial that could lead to a new treatment option for women
with MS. Its results may also have implications for women with other
autoimmune diseases, such as rheumatoid arthritis.
* Several oral MS therapies continued to progress through the pipeline:
-- a phase II controlled clinical trial of oral fingolimod (FTY720,
Novartis Pharmaceuticals Corp.) in 255 people with active, relapsing
MS found that up to 77% of those taking fingolimod remained free of
relapses over two years; a large phase III trial is now underway;
-- oral cladribine (an immune-modulating drug by Serono), now being
tested in an international Phase 3 clinical trial, has been
designated by the FDA as a "Fast Track Product," which should
expedite its future review;
-- a multicenter, phase II controlled clinical trial of oral BG00012 (an
oral fumarate, Biogen Idec) led to a 69% reduction in active
inflammation on MRI scans in 257 people with relapsing-remitting MS;
-- in an open-label, 144-week extension study of oral teriflunomide (an
agent that may modulate T cells), those on placebo during the
original trial who switched to teriflunomide experienced up to an 85%
decrease in new, active areas of disease activity seen on MRI at week
144.
* Harvard investigators reported that individuals who showed signs of
significant exposure to the Epstein-Barr virus, which causes infectious
mononucleosis and other disorders, were twice as likely to develop MS up
to 20 years later. The study, funded in part by a grant from the
National MS Society, adds to previous evidence linking the virus to the
risk of developing MS, but does not prove that EBV actually causes MS.
Other recent studies have suggested that smoking cigarettes may
contribute to the risk of MS and MS progression, and that higher vitamin
D intake may help protect against developing MS.
* For the first time, the needs of children who develop MS-like symptoms
are being addressed through the Society's nationwide network of
comprehensive Pediatric MS Centers of Excellence, launched early this
year. The 6 centers have committed to sharing critical resources and
best practices such as MRI protocols and neuropsychological evaluations
so that all families can benefit from the collective knowledge of the
entire network. In addition to providing optimal care and support,
these centers will build a framework for research into this patient
population, which may also provide clues to adult MS.
* Two genes that may contribute to making a person susceptible to
developing MS have been identified by a group of European researchers
known as the "GAMES" Collaborative Group. MS involves an immune-system
attack on the body's own brain and spinal cord, and many genes are
thought to contribute to susceptibility. The two candidate genes were
singled out because they encode for a brain tissue component and an
immune component. This work was supported in part by the National MS
Society.
* Researchers at Stanford University have uncovered evidence they believe
may explain the role of a protein, osteopontin, in stimulating repeated
relapses and disease progression as well as inhibiting spontaneous
recovery from symptoms. This research, sponsored in part by the
Society, could lead to new therapeutic approaches that target
oseopontin's effect in the MS disease process.
* The National MS Society launched a new postdoctoral fellowship program
in MS rehabilitation research. The immediate goal is to recruit and
train talented clinician-scientists in rehabilitation research specific
to MS; the ultimate goal is to get more hands and minds working on ways
to help people with MS maximize their abilities.
During 2006, rapid research progress
was made in the fields of science and medicine that impact understanding
and treatment of multiple sclerosis, an unpredictable neurological disease.
Significant advances have been made in both clinical and laboratory
studies in MS. In addition, more than 130 clinical trials are underway
around the world, and still other experimental drugs are in the pipeline.
Key highlights of the year include:
* Acorda Therapeutics (Hawthorne, NY) announced positive results of a
Phase 3, placebo-controlled clinical trial of Fampridine-SR, an oral
drug designed to provide symptomatic relief by compensating for lost
nerve conduction. In 301 patients with all types of MS, those on active
treatment showed an average increase in walking speed of 25% versus
those on inactive placebo. The company is expected to meet with the
U.S. Food and Drug Administration (FDA) to determine next steps needed
to apply for marketing approval.
* The FDA approved the return to market of Tysabri(R) (natalizumab,
produced by Biogen Idec and Elan Pharmaceuticals) to delay the
accumulation of physical disability and reduce the frequency of relapses
(clinical exacerbations) in those with relapsing MS. There is now in
place a mandatory registration program for patients and prescribing
physicians to minimize the risk of PML (progressive multifocal
leukoencephalopathy), caused by a common virus called the JC virus. The
drug is dispensed at registered infusion centers across the country.
Since Tysabri's return to market last summer, there have been no new
cases of PML reported.
* Members of the four Nervous System Repair teams from Europe and the U.S.
met to share progress being made in the Society funded Promise: 2010
initiative. The first clinical trials focused on protecting the nervous
system will begin shortly, and trials aimed at repairing damage and
restoring function in people with MS are expected to begin within the
next five years.
* In a first, Johns Hopkins University researchers reported that nerve
cells derived from mouse embryonic stem cells that were transplanted
into rats with spinal cord injury were able to connect with muscles and
partially restore function. While this work was done in a model of
spinal cord injury, it bears relevance to the potential use of cell
replacement to repair damage in MS.
* The Society will be sponsoring the first ever stem cell summit January
16-19 in San Francisco to explore the potential of the complete spectrum
of stem cell options as they might relate to MS research and treatment.
The by-invitation only meeting will bring together some 60 renowned
scientists from around the world to examine stem cell prospects and
strategies in MS. The results of this meeting are expected to set
research directions and priorities to best determine the potential of
all types of stem cells for treating this disease.
* Researchers from the University of California, Los Angeles reported that
administering Androgel(R) (testosterone gel applied to the skin) to 10
men with relapsing-remitting MS significantly improved cognitive
function and slowed brain tissue loss. This study was funded by the
Society's initiative on Gender Differences in MS and is expected to lead
to additional research involving larger numbers of patients to confirm
these early results.
* In another offshoot from the Society's initiative on Gender Differences,
UCLA investigators began the first large-scale trial of a sex hormone
for the treatment of MS. The two-year, controlled clinical trial of
estriol involves 130 women with early relapsing-remitting MS. If
successful, this clinical trial will lay the groundwork for a larger,
definitive trial that could lead to a new treatment option for women
with MS. Its results may also have implications for women with other
autoimmune diseases, such as rheumatoid arthritis.
* Several oral MS therapies continued to progress through the pipeline:
-- a phase II controlled clinical trial of oral fingolimod (FTY720,
Novartis Pharmaceuticals Corp.) in 255 people with active, relapsing
MS found that up to 77% of those taking fingolimod remained free of
relapses over two years; a large phase III trial is now underway;
-- oral cladribine (an immune-modulating drug by Serono), now being
tested in an international Phase 3 clinical trial, has been
designated by the FDA as a "Fast Track Product," which should
expedite its future review;
-- a multicenter, phase II controlled clinical trial of oral BG00012 (an
oral fumarate, Biogen Idec) led to a 69% reduction in active
inflammation on MRI scans in 257 people with relapsing-remitting MS;
-- in an open-label, 144-week extension study of oral teriflunomide (an
agent that may modulate T cells), those on placebo during the
original trial who switched to teriflunomide experienced up to an 85%
decrease in new, active areas of disease activity seen on MRI at week
144.
* Harvard investigators reported that individuals who showed signs of
significant exposure to the Epstein-Barr virus, which causes infectious
mononucleosis and other disorders, were twice as likely to develop MS up
to 20 years later. The study, funded in part by a grant from the
National MS Society, adds to previous evidence linking the virus to the
risk of developing MS, but does not prove that EBV actually causes MS.
Other recent studies have suggested that smoking cigarettes may
contribute to the risk of MS and MS progression, and that higher vitamin
D intake may help protect against developing MS.
* For the first time, the needs of children who develop MS-like symptoms
are being addressed through the Society's nationwide network of
comprehensive Pediatric MS Centers of Excellence, launched early this
year. The 6 centers have committed to sharing critical resources and
best practices such as MRI protocols and neuropsychological evaluations
so that all families can benefit from the collective knowledge of the
entire network. In addition to providing optimal care and support,
these centers will build a framework for research into this patient
population, which may also provide clues to adult MS.
* Two genes that may contribute to making a person susceptible to
developing MS have been identified by a group of European researchers
known as the "GAMES" Collaborative Group. MS involves an immune-system
attack on the body's own brain and spinal cord, and many genes are
thought to contribute to susceptibility. The two candidate genes were
singled out because they encode for a brain tissue component and an
immune component. This work was supported in part by the National MS
Society.
* Researchers at Stanford University have uncovered evidence they believe
may explain the role of a protein, osteopontin, in stimulating repeated
relapses and disease progression as well as inhibiting spontaneous
recovery from symptoms. This research, sponsored in part by the
Society, could lead to new therapeutic approaches that target
oseopontin's effect in the MS disease process.
* The National MS Society launched a new postdoctoral fellowship program
in MS rehabilitation research. The immediate goal is to recruit and
train talented clinician-scientists in rehabilitation research specific
to MS; the ultimate goal is to get more hands and minds working on ways
to help people with MS maximize their abilities.
Latest Comments
From Subject Time Posted
1 NEW! » Jeannine Elan Extends Tysabri's Reach to Canada Oct 8 2006 07:46
1 NEW! » Jeannine 10 Top Australian Scientists Predict Major Medical Advances in MS (download free report) Oct 10 2006 13:11
1 NEW! » Jeannine NEUROVAX: PRESS RELEASE FROM IMMUNE RESPONSE CORP. Oct 10 2006 13:06
1 NEW! » "Gamma Julie" Should Job Hunters Reveal Chronic Illness? The Pros and Cons..[update] Oct 31 2006 03:41
1 NEW! » Jeannine HUMAN STEM CELLS DELAY START OF LOU GEHRIG'S DISEASE IN RATS Oct 15 2006 10:02
1 NEW! » Jeannine Tysabri and Avonex add customer service reps Oct 17 2006 07:34
1 NEW! » Jeannine "Take 10 laps and call me in the morning" Oct 17 2006 09:15
1 NEW! » Jeannine "inmate moved to hospital" (AN UPDATE OF LAST WEEKS STORY: "INMATE WITH MS" Oct 17 2006 09:42
1 NEW! » Jeannine Fampridine SR - NEW DRUG IN PIPELINE Oct 18 2006 09:42
1 NEW! » Jeannine [PROFESSIONAL ABSTRACT] Oct 18 2006 09:43
1 NEW! » David "Copaxone allows some MS patients to retain mobility" Oct 19 2006 19:50
1 NEW! » Lora Future-directed thinking and depression in MS [READ LIZZY'S COMMENT!!!] Oct 28 2006 15:03
1 NEW! » Jeannine MS BIKE TREK Oct 19 2006 09:38
1 NEW! » WaterDragon STEM CELL: "Federal government promotes donation of umbilical cords for stem cell transplants" Oct 20 2006 00:51
1 NEW! » Jeannine Development of an anti-IL-17A auto-vaccine... Oct 20 2006 09:05
1 NEW! » Jeannine GREAT PERSONAL STORY: Oct 20 2006 15:17
1 NEW! » Jeannine "Acute leukaemia in two multiple sclerosis patients treated with mitoxantrone" Oct 20 2006 15:21
1 NEW! » Jeannine The Effect of dose and frequency of interferon beta-1a administration Oct 20 2006 15:31
1 NEW! » Jeannine CDP323: NEW DRUG IN PIPLINE Oct 21 2006 09:58
1 NEW! » Jeannine Did you know that Colorado has one of the highest prevalence rates of MS in the US Oct 21 2006 09:59
1 NEW! » Jeannine Write in Candidate Denise Clement will work for free! Oct 21 2006 10:00
1 NEW! » Jeannine Methylthioadenosine Effective in Animal Models of Multiple Sclerosis Oct 22 2006 07:32
1 NEW! » Jeannine UK: cannabis pill test Oct 22 2006 07:34
1 NEW! » Jeannine Clustering of autoimmune diseases in families with a high-risk for MS: Oct 23 2006 07:36
1 NEW! » Jeannine The female to male sex ratio by year of birth has been increasing for at least 50 years Oct 23 2006 07:39
1 NEW! » Jeannine Photography studio is donating fees to MS Oct 23 2006 08:17
1 NEW! » Jeannine Boston Home's 125th Anniversary - Oct 24 2006 09:28
1 NEW! » Jeannine UK...MP's Back MS Campaign Oct 24 2006 09:32
1 NEW! » Jeannine Dutch prosecutors ask highest court to quash appeals court medicinal cannabis decision Oct 24 2006 09:34
1 NEW! » Jeannine MBP8298 Oct 24 2006 09:35
1 NEW! » deleted account Live HealthTalk - 30 Minutes of Q&A with Nurse Piper [sponsored by a drug company] Oct 24 2006 19:50
1 NEW! » Jeannine High-Dose Cyclophosphamide Study: GOOD RESULTS!!! Oct 25 2006 09:32
1 NEW! » Jeannine NEW DRUG IN PIPELINE: MCT-125 Oct 25 2006 09:35
1 NEW! » Jeannine 3 Guys, 3 Bikes, 7,000 Miles Through South America for MS Oct 25 2006 09:39
1 NEW! » Jeannine 14-year old bicyclist rides for MS Oct 26 2006 08:24
1 NEW! » Jeannine Accelerated Cure Project for MS today announced the formation of their MS Repository Oct 26 2006 08:29
1 NEW! » Jeannine A MSnewsChannel.com Video: A TIP FROM HEATHER ON EASING REBIF PAIN Oct 26 2006 09:02
1 NEW! » Jeannine TYSABRI® GOOD FOR LUPUS TOO...PER THIS PRESS RELEASE FROM ELAN Oct 26 2006 09:04
1 NEW! » Jeannine VISIT OUR "TYSABRI NEWS" WEBSITE Oct 26 2006 09:08
1 NEW! » Jeannine Joseph Eisen suffers from Primary Progressive Multiple Sclerosis....AGENGY HELPS WITH HIS LEGAL Oct 27 2006 08:18
1 NEW! » Jeannine Campus Fudraiser....(good idea for other colleges) Oct 27 2006 14:22
1 NEW! » David WATCH VIDEO: Selling CDs as a MS Fundraiser Oct 29 2006 09:03
1 NEW! » Jeannine If a sibling has MS, you are 15 to 25 times more likely to develop it yourself Oct 29 2006 09:16
1 NEW! » Jeannine UK: NO JAIL FOR HUSBAND WHO HELPED WIFE'S SUICIDE Oct 29 2006 09:18
1 NEW! » Jeannine Car enthusiasts, bikers rally MS Oct 29 2006 09:26
1 NEW! » Jeannine UPDATE ON MS CANDIDATE WHOSE OPPONENT MADE A NASTY WHEELCHAIR COMMENT Oct 30 2006 08:32
2 NEW! » Jeannine "MS NO LONGER A DEATH KNELL FOR PATIENTS" Oct 30 2006 08:43
2 NEW! » David WATCH VIDEO PLUS FREE READ OF CHAPTER 1 : Today show host Meredith Vieira talks with Teri Garr Oct 30 2006 20:27
1 NEW! » WaterDragon "Ed Johns says he feels like a new man" [I WOULDN'T LET MY SON DO THIS!-stan] Oct 31 2006 01:11
1 NEW! » Jeannine TYSABRI.....Biogen Idec Third-Quarter Net Rises Sixfold on MS Drugs Oct 31 2006 09:18
1 NEW! » Jeannine DETROIT FUNDRAISER Nov 1 2006 10:08
1 NEW! » Jeannine ABSTRACT FOR DOCS, NURSES Nov 1 2006 10:09
2 NEW! » Jeannine .....control of their health with exercise, even though it might bring short-term discomfort Nov 1 2006 15:05
1 NEW! » Darth Woky ™ GREAT READ: MS afflicts about twice as many females as males Nov 2 2006 01:15
2 NEW! » David Cladribine used to treat some cancers and possibly MS: Brigham Young University Nov 2 2006 19:15
2 NEW! » David I JUST RECEIVED THIS PRESS RELEASE FROM TEVA RE: COPAXONE {NOT IMPORTANT :-)] Nov 2 2006 19:23
2 NEW! » David VOTE: ANOTHER STEM CELL STORY(I can't decide if I should post stem cell stories or not?? -stan) Nov 2 2006 19:33
3 NEW! » David update: DRUG DELAYED BY FDA FOR A MS CONDITION I'VE NOT HEARD OF -HAVE YOU??? -stan Nov 2 2006 19:36
2 NEW! » David MS Linked to Abnormal Liver Test Results Nov 2 2006 19:46
1 NEW! » Rev. cutthroat carnie TYSABRI BAD NEWS:Since July, only 47 of more than 8,500 patients are using Tysabri... Nov 7 2006 08:13
1 NEW! » Jeannine New York City Chapter MS Society: Help Us Reach Our Fundraising Goal for the MS Bike Tour Nov 1 2006 14:43
1 NEW! » Jeannine BAD NEWS ON UCLA PLAYER WE HAVE BEEN REPORTING ON Nov 2 2006 08:27
1 NEW! » Jeannine !!!...Fampridine-SR: WONDERFUL TRIAL RESULTS ON NEW DRUG Nov 2 2006 08:29
2 NEW! » queen_racewife PRESS RELEASE ON NEW DRUG: MBP8298 [TRIALS ARE VERY GOOD OUT OF THE US!!!] Nov 2 2006 08:35
1 NEW! » Mary and Robert GREAT STORY OF PERSEVERANCE Nov 2 2006 10:40
1 NEW! » Jeannine Study sheds light on myelination Nov 3 2006 07:04
1 NEW! » Jeannine FDA Approvals: Interferon-beta-1b (Betaseron) for Use in Early Multiple Sclerosis Nov 3 2006 18:13
1 NEW! » "Gamma Julie" 'miracle drug' is supposedly no good Nov 4 2006 02:01
2 NEW! » Roseanne ENVIRONMENT CAUSE OF WOMEN'S HIGHER RISK OF MS? Nov 4 2006 09:05
1 NEW! » Jeannine cladrabine Nov 4 2006 14:09
2 NEW! » Jeannine MS Society's 'Shining Star Nov 4 2006 14:30
1 NEW! » Jeannine NEW DRUG IN PIPELINE: MBP8298 Nov 4 2006 14:33
3 NEW! » David UK - EXPERTS believe they have discovered a protein which could help create new MS treatments Nov 4 2006 18:14
1 NEW! » Jeannine WONDERFUL STORY OF PERSEVERANCE IN THIS SUNDAY'S NYC MARATHON Nov 5 2006 12:08
1 NEW! » ~Ãngël~™ NPR AUDIO: Studies have found that a six-month Iyengar yoga program helped people with MS comba Nov 5 2006 17:35
2 NEW! » Jeannine "advances on the horizon..." Nov 6 2006 09:12
1 NEW! » Jeannine GREAT ADVICE FOR CAREGIVERS - stan Nov 6 2006 09:28
2 NEW! » Darth Woky ™ (UPDATE ON THIS STORY IS AB0VE) CHURCHILL DOWNS PERSEVERANCE Nov 7 2006 01:22
2 NEW! » "Gamma Julie" Award given to Scott Johnson, President and Founder of the Myelin Repair Foundation Nov 7 2006 04:46
2 NEW! » queen_racewife INTERESTING IMPLANT STUDY....update Nov 8 2006 03:38
1 NEW! » David (READ THE GREAT COMMENTS) TOVAXIN...NEW MS DRUG IN PIPELINE STARTS DOSING Nov 9 2006 22:56
2 NEW! » Lora GOOD INTERVIEW WITH AUTHOR OF NEW BOOK: ABOUT HER MS Nov 10 2006 13:39
2 NEW! » Mary and Robert Man says tai chi gave him second chance at life. Nov 10 2006 17:20
3 NEW! » Jeannine oral Trimesta (estriol)...A NEW MS DRUG IN THE PIPELINE!!!!! [UPDATE] Nov 10 2006 18:54
1 NEW! » Jeannine STORY OF 37-YEAR OLDS PERSEVERANCE Nov 10 2006 19:00
1 NEW! » Jeannine NEW BROCHURE: Volunteering for a Clinical Trial: Your Guide to Participating in a Trial Nov 10 2006 19:01
1 NEW! » Jeannine ECCO Shoes Plans to Donates $2 Per Pair of Shoes Sold to MS [good idea for US] Nov 10 2006 19:08
1 NEW! » Jeannine 58% of long-term care claimants are younger than 65 and the top five claims causes are MS, Canc Nov 10 2006 19:09
3 NEW! » Jeannine "Advances on the horizon in treating and curing MS" Nov 10 2006 19:15
1 NEW! » Jeannine A medical marijuana ballot in South Dakota Today Nov 10 2006 19:17
1 NEW! » Jeannine study identifies how treatment can limit impact of T-cells in autoimmune diseases Nov 10 2006 19:19
1 NEW! » Jeannine MS fundraising luncheon in Ne Jersey Nov 10 2006 19:19
1 NEW! » Jeannine Treatment of neuropsychiatric conditions associated with MS Nov 10 2006 19:21
1 NEW! » Jeannine BREEDERS CUP WIN! McLaughlin on his battle with MS (THE STORY ON THIS FROM LAST WEEK IS BELOW) Nov 10 2006 19:23
1 NEW! » Jeannine PERSEVERANCE: PAT KINSLEY GIVE BACK TO KIDS Nov 10 2006 19:27
1 NEW! » Jeannine GREAT AND IMPORTANT STORY ABOUT DOGS AS HELPERS FOR MS PATIENTS - stan Nov 10 2006 19:28
2 NEW! » Jeannine FDA APPROVAL: BETASERON UPDATE Nov 10 2006 19:30
2 NEW! » Jeannine ELK HUNTING & MS STORY Nov 10 2006 19:32
2 NEW! » Jeannine B12 and MS: UK MS SOCIETY EDITORIAL Nov 10 2006 19:33
3 NEW! » Mary and Robert Help fight multiple sclerosis with me - The Bakersfield Voice Nov 11 2006 02:06
2 NEW! » Mary and Robert {PERSEVERANCE}.....Cheri Piekarski's job is a labor of love Nov 11 2006 13:41
1 NEW! » Jeannine MARY MOLDS' MS DOESN'T STOP HER FROM HELPING OTHERS Nov 12 2006 08:05
3 NEW! » ♥Debbie♥ GOOD WHEELCHAIR NEWS: Battle over Payments Cuts by CMS is being won!!!! Nov 13 2006 08:24
3 NEW! » David "I believe that a person who can't read in our society is more handicapped than I am," Merens s Nov 13 2006 20:35
2 NEW! » Key two-headed snake Nov 13 2006 20:42
2 NEW! » MRSMUSTAINE NEW PATENTS FOR MS MED Nov 14 2006 02:08
1 NEW! » "Gamma Julie" Cannabis Study in news this AM Nov 15 2006 01:39
1 NEW! » "Gamma Julie" memory study Nov 15 2006 01:52
3 NEW! » "Gamma Julie" "Research Highlights" from the New York City Chapter of the National Multiple Sclerosis Society Nov 15 2006 01:59
1 NEW! » "Gamma Julie" GREAT ARTICLE...THINGS ABOUT RICHARD PRYOR & HIS DAUGHTER RAIN THAT HAVE NEVER BEEN TOLD!-stan Nov 15 2006 02:17
1 NEW! » "Gamma Julie" GETTING TOUGH ON MEDICINAL POT SELLERS Nov 15 2006 02:29
1 NEW! » queen_racewife SAMANTHA..PERSEVERANCE AND KINDNESS AT 15 YEARS OLD...."SHE IS MY REAL HERO"-stan Nov 15 2006 17:28
2 NEW! » queen_racewife BNC105: PRESS RELEASE ON THIS NEW DRUG IN PIPLINE Nov 15 2006 17:42
4 NEW! » queen_racewife STEM CELL STORY FROM THE UK Nov 15 2006 17:47
1 NEW! » David "laughing and intractable hiccups can occur early in MS" [study] Nov 16 2006 20:02
4 NEW! » David New Wave Of HOPE- Support Group Aims To Aid MS Patients Nov 17 2006 20:25
2 NEW! » David Amy Clawson: Country music artist Nov 17 2006 20:32
1 NEW! » David TYSABRI: Natalizumab Alters T Cell Ratio in MS Patients (Reuters Health) Nov 19 2006 10:09
2 NEW! » Alpha [GREAT READ] Geographical disparity of Diseases Nov 19 2006 18:55
1 NEW! » Jenn MBP8298: NEW DRUG IN PIPELINE Nov 19 2006 20:13
4 NEW! » Jenn ANOTHER CRAZY STORY FROM THE UK: "FREEZE TREATMENT FOR MS" Nov 19 2006 20:24
1 NEW! » Tim Foolery There are a lot of new things in Krystal Hexamer's life: Research Promises New Treatment for MS Nov 20 2006 07:38
4 NEW! » Stacey OUR FRIEND LARRY NEEDS YOUR HELP: BOTH HE AND HIS MOM HAVE MS Nov 24 2006 07:56
3 NEW! » Shell THIS IS WHY I LOVE MySpace...AND MY MySpace FRIENDS - stan Nov 24 2006 11:36
1 NEW! » Mary and Robert Wheelchair bowlers still rolling Nov 18 2006 16:53
1 NEW! » David THIS POST CAME FROM OUR CORRESPONDENT ANNE: A SIMPLE TEST FOR MS Nov 19 2006 10:27
1 NEW! » Darth Woky ™ CLEVELAND CLINIC TIPS ON: STRESS AND MS Nov 20 2006 01:35
3 NEW! » ♥Debbie♥ "FAMOUS PATIENTS AND THE LESSONS THEY TEACH"...THE NEW YORK TIMES Nov 20 2006 05:11
4 NEW! » Tim Foolery Stem cells might cause brain tumors Nov 20 2006 07:22
1 NEW! » WaterDragon {READ THIS!!!-stan} DRUG COMBO SHOWS SHOCKING REVERSAL OF MS SYMPTOMS Nov 21 2006 04:36
1 NEW! » WaterDragon "What if we could actually reverse the damage that MS causes, restoring function..." Nov 21 2006 05:10
1 NEW! » Jeannine Stada said it is no longer to pursue its Interferon-beta project to treat MS Nov 21 2006 07:28
4 NEW! » Shell Clinical Trial Design Nov 22 2006 07:48
4 NEW! » Alpha STUDY FINISHED RE: people's concern about a perceived high rate of MS in Illinois cities Nov 22 2006 11:20
5 NEW! » David New Patent for diagnosing MS Nov 22 2006 13:17
1 NEW! » Roseanne GREAT EXPLANATION OF STEM CELLS AND THEIR POSSIBLE USE IN MS Nov 23 2006 07:37
2 NEW! » Alpha PERSONAL STORY OF THANKSGIVING Nov 23 2006 20:52
3 NEW! » Alpha SOUTH FLORIDA - National MS Health Expo Is November 19th Nov 24 2006 17:06
4 NEW! » Jeannine YOUR COMMENTS HAVE HELPED "FOOL ON THE HILL"...stan Nov 24 2006 19:00
3 NEW! » "Gamma Julie" {first time i've seen a charity benefit solely for low income ms patients-stan} Nov 25 2006 07:08
5 NEW! » Mary and Robert Multiple Sclerosis Society Alert re: funding Nov 25 2006 23:44
3 NEW! » Mary and Robert DACLIZUMAB FOR MS Nov 25 2006 23:46
4 NEW! » queen_racewife GOOD STORY - University of Rochester presses quest for stem cell breakthrough Nov 26 2006 10:50
5 NEW! » Alpha [WOW!!! READ THIS!!-stan] High-tech device helps a martial artist learn how to walk again Nov 26 2006 16:18
2 NEW! » Kendra OUR FRIEND KENDRA NEEDS OUR WISHES OF GOOD LUCK! HER SURGERY IS APPROACHING - stan Nov 27 2006 08:17
5 NEW! » Alpha Results of study on prevalence of MS in Lewistown to be presented Nov 28 2006 08:36
2 NEW! » ♥Debbie♥ "Do you believe in miracles? " By Linda Beck Nov 28 2006 10:02
1 NEW! » ♥Debbie♥ OUR FRIEND AND "STAR COMMENTATOR" KEY HAS GOOD NEWS Nov 28 2006 10:06
3 NEW! » ♥Debbie♥ THIS IS GREAT: FREE BOOKLET FROM THE UK Nov 28 2006 10:14
1 NEW! » ~♥sweet caroline♥~ OUR FRIEND DEBBIE NEEDS A HUG! SHE HAS A MESSAGE FOR EVERYONE Nov 28 2006 21:01
1 NEW! » Francine MS Holiday Gift Guide Nov 29 2006 08:07
8 NEW! » David "Glatiramer acetate therapy for multiple sclerosis" Nov 29 2006 19:30
1 NEW! » David DARTH WOKY: ONE OF MY BEST FRIENDS NEEDS YOUR ADVICE Dec 2 2006 12:38
3 NEW! » ♥Debbie♥ [update-18 comments] JENNIFER NEEDS SUPPORT: "MY LEGS ARE STIFF & LIFELESS" Dec 4 2006 08:14
2 NEW! » Anne SAD STORY FROM TODAYS HEADLINES Dec 5 2006 05:06
4 NEW! » Anne MELISSA NEEDS SUPPORT Dec 5 2006 05:32
2 NEW! » Kendra NO MERCURY RISK IN AMALGAM FILLINGS Dec 5 2006 08:16
2 NEW! » queen_racewife KIDS: "Why are our children's bodies attacking them? Dec 6 2006 02:55
4 NEW! » queen_racewife PERSEVERANCE: GREAT STORY Dec 6 2006 03:07
1 NEW! » queen_racewife HIGH INCIDENCE OF MS IN ILLINOIS TOWN PUZZLES RESEARCHERS Dec 6 2006 03:23
5 NEW! » queen_racewife PERSEVERANCE: GREAT RADIO INTERVIEW Dec 6 2006 03:35
2 NEW! » Shell PERSEVERANCE...Susan Greenop"s personal story Dec 6 2006 04:49
7 NEW! » Alpha STEM CELL STUDY Dec 6 2006 09:32
3 NEW! » (¯`•´¯)Starr(¯`•´¯) ARTISTS FOR MS Dec 6 2006 09:53
8 NEW! » Mich/Neurotrash'd TERI GARR Dec 7 2006 10:18
1 NEW! » Sean GREAT DISCOVERY AT STANFORD MED SCHOOL: Molecule Linked to Autoimmune Disease Relapses Found Dec 8 2006 15:54
2 NEW! » Mary and Robert GIVE CONGRATS TO TIM FOOLERY FOR GETTING A RAISE! Dec 8 2006 19:12
8 NEW! » David Prescription for the Soul Dec 8 2006 21:07
7 NEW! » Alpha GREAT NEW DRUG: Fampridine-SR Dec 9 2006 12:05
7 NEW! » (¯`•´¯)Starr(¯`•´¯) DISABLED STILL FACE OBSTACLES Dec 9 2006 14:31
5 NEW! » Rev UPDATE ON POT IN CANDY BARS FROM YESTERDAY Dec 10 2006 10:57
4 NEW! » ~Ãngël~™ UPDATE: 36 COMMENTS- ADD YOUR STORY & SHARE YOUR ADVICE: MS IS INTERFERING IN ANGEL'S LOVE LIFE Dec 10 2006 11:16
1 NEW! » Wendy SENATE PASSES GREAT NEW BILL FOR MS Dec 11 2006 08:04
5 NEW! » Tim Foolery "Activists are convinced that electrical pollution is making us sick" Dec 11 2006 09:31
6 NEW! » Tim Foolery GREAT STORY OF PERSEVERANCE FROM TODAY'S HEADLINES Dec 11 2006 09:32
1 NEW! » Tim Foolery CONGRATS TO LORA: SHE'S ALMOST DONE WITH LAW SCHOOL Dec 11 2006 09:33
6 NEW! » Tim Foolery A happy fundraising story - stan Dec 11 2006 14:29
2 NEW! » Jenn CONGRATS TO JENN: "I found out last Monday that hubby and I are expecting .2" Dec 11 2006 18:50
7 NEW! » Yvonne UPDATE ON YESTERDAYS TYSABRI STORY: "1000 MS PATIENTS REFUSED TYSABRI: IT COSTS TOO MUCH! Dec 12 2006 06:54
3 NEW! » Renee JILL'S BDAY IS TODAY...PLUS CONGRATS TO HER ON GRAD SCHOOL!! - stan Dec 13 2006 09:43
1 NEW! » WaterDragon 2 IMPORTANT NEW STUDIES ON GRAY MATTER DAMAGE IN MS Dec 14 2006 04:50
6 NEW! » Alpha MS FAMILY BATTLES LYME DISEASE Dec 14 2006 12:14
1 NEW! » Patti (aka Thelma) UPDATE ON MY POST FROM DECEMBER 4TH: "SIF IS GETTING CHEMO TOMORROW" Dec 14 2006 23:18
4 NEW! » Jeannine TYSABRI: RICH WANTS TO TAKE IT ...BUT HAS A QUESTION Dec 15 2006 07:02
5 NEW! » ~Ãngël~™ GREAT STORY ON NEW JERSEY BIKE TEAM Dec 15 2006 09:44
3 NEW! » ~♥sweet caroline♥~ SUPPORT TEAM ALERT: ANGEL HAS HELPED MANY OTHERS-NOW SHE NEEDS OUR SUPPORT - stan Dec 15 2006 16:08
3 NEW! » CARRIE AMAZING NEWS! CONGRATS TO EVERYONE WHO HAS BEEN MAKING COMMENTS! LOOK AT THIS INFO: Dec 15 2006 20:55
7 NEW! » David CONTROVERSIAL CLINIC SHUT DOWN Dec 15 2006 21:40
7 NEW! » Mary and Robert SAD STORY ABOUT JAZZ SINGER Dec 16 2006 14:58
2 NEW! » David "1000 PATIENTS IN THE UK TO BE DENIED TYSABRI: NOT COST EFFECTIVE" Dec 17 2006 12:25
1 NEW! » David BILLY TALLENT: one of my fav bands [my favorite is Hatebreed] - stan Dec 17 2006 13:37
5 NEW! » Jeannine A MESSAGE FROM ONE OF OUR SUPPORT ANGELS: ALPHA...WHO IS STRANDED IN SEATTLE! -stan Dec 18 2006 14:37
4 NEW! » Jeannine TYSABRI FOR CROHN'S DISEASE TOO!!!! Dec 18 2006 14:40
1 NEW! » Jeannine GREAT NEWS ON NEW MS DRUG FOR MS FATIGUE: MCT-125 Dec 18 2006 14:40
5 NEW! » Jeannine GIVE SPHILLY CONGRATS ON GETTING APPROVED FOR A GRANT Dec 18 2006 14:42
6 NEW! » Jeannine "HAPPY NEWS" FROM OUR SUPPORT ANGEL ANNE - stan Dec 18 2006 14:44
2 NEW! » Jeannine SUPPORT GROUP ALERT: I HAVE RECEIVED MANY EMAILS THIS WEEK FROM OUR FRIENDS WHO ARE SAD Dec 18 2006 14:46
3 NEW! » WaterDragon SUPPORT ALERT: "i have been just feeling like why me why did i have to have ms!" - TERI Dec 18 2006 16:57
4 NEW! » SPhilly SUPPORT ALERT: GIVE RainMaker A PAT ON THE BACK FOR STARTING HIS MS TREATMENT - stan Dec 18 2006 22:30
2 NEW! » Darth Woky ™ CONGRATS TO OUR ANGELS OF SUPPORT: YOUR ADVICE HELPED Holy Crip Dec 19 2006 01:32
4 NEW! » <3i data-blogger-escaped--="" data-blogger-escaped-09:57="" data-blogger-escaped-19="" data-blogger-escaped-2006="" data-blogger-escaped-at="" data-blogger-escaped-br="" data-blogger-escaped-coming="" data-blogger-escaped-dec="" data-blogger-escaped-drug="" data-blogger-escaped-glass="" data-blogger-escaped-great="" data-blogger-escaped-looking="" data-blogger-escaped-m="" data-blogger-escaped-new="" data-blogger-escaped-oral="" data-blogger-escaped-soon...hopefully="" data-blogger-escaped-stan="" data-blogger-escaped-the="" data-blogger-escaped-through="" data-blogger-escaped-you="">1 NEW! » (¯`•´¯)Starr(¯`•´¯) 1,039 FRIENDS VISITED OUR BLOG YESTERDAY & READ YOUR 125 COMMENTS!!!!!!!!!!! - stan Dec 19 2006 10:15
4 NEW! » (¯`•´¯)Starr(¯`•´¯) TERI & ALPHA THINK THIS STORY WILL HELP EXPLAIN MS TO YOUR FAMILY: IT'S ALSO ON TYSABRI - stan Dec 19 2006 10:20
1 NEW! » Melissa NEW PAIN DRUG APPROVED FOR MS...IN EUROPE...WHICH MEANS IT WILL HOPEFULLY BE HERE SOON - stan Dec 19 2006 15:10
4 NEW! » Kim SUPPORT ALERT: BOTH SUSAN AND I NEED HELP! - stan Dec 19 2006 19:33
9 NEW! » Jeannine HAPPY HOLIDAY STORY IN TODAY' NEWS -stan Dec 20 2006 09:55
2 NEW! » Jeannine GIVE CHRIS...OUR NEWSEST ANGEL OF SUPPORT A HUG - stan Dec 20 2006 10:05
4 NEW! » Jeannine POSSIBLE NEW MS TREATMENT: SOY!!!!!!!!!!!!!!!! Dec 20 2006 10:27
5 NEW! » Jeannine INTERESTING STUDY ON RURAL VS URBAN USE OF DOCTORS IN MS PATIENTS Dec 20 2006 10:30
4 NEW! » Jeannine DIABETES BREATHROUGH - RELATIONSHIP TO MS? SEE MY POST ABOVE FROM VIVIAN Dec 20 2006 10:34
1 NEW! » Jeannine AN INTERESTING EMAIL ON DIABETES CURE AND I'S RELATION TO MS Dec 20 2006 10:35
7 NEW! » David THIS STORY IS BETTER THAN THE TRASH FICTION BOOKS I LOVE TO READ - stan Dec 20 2006 20:21
6 NEW! » David NEW MS DRUG UPDATE IN THE NEWS: CHR-1103 Dec 20 2006 20:23
4 NEW! » David UPDATE: FDA ADVISORY (WARNING) 2 Rituxan deaths: of Tysabri type..rare brain infection Dec 20 2006 20:30
7 NEW! » There Can Only Be One Me SUPPORT ALERT FOR FRANCINE - SHE HAS HELPED MANY FRIENDS - NOW SHE NEEDS HUGS! - stan Dec 21 2006 06:58
2 NEW! » Jeannine COGNITIVE TRAINING HELPS SENIORS" [STUDY] MAYBE IT WILL HELP MS TOO??? Dec 21 2006 06:59
1 NEW! » Miss Kitty MY MESSAGE TO OUR ANGELS OF SUPPORT- RE: YOUR 2 HOLIDAY GIFTS FROM ME + HELP 4 FRIENDS -stan Dec 21 2006 11:10
7 NEW! » :Vitamin DEE: STORY ON NEW MS DRUG IN THE PIPELINE: NEUROVAX Dec 21 2006 21:31
3 NEW! » queen_racewife READ 42 COMMENTS-MARIES IMPORTANT UPDATE ON HER Dec 22 2006 05:43
2 NEW! » (¯`•´¯)Starr(¯`•´¯) DEBBIE'S CHRISTMAS MESSAGE TO OUR Angels of Support Dec 22 2006 10:03
7 NEW! » (¯`•´¯)Starr(¯`•´¯) GREAT STORY OF A MED STUDENT'S PERSEVERANCE IN TODAYS HEADLINE NEWS - stan Dec 22 2006 10:20
7 NEW! » Anne ANOTHER SUCCESS FOR OUR Angel of Support KELLI'S VIDEO - stan Dec 22 2006 16:55
1 NEW! » Patti (aka Thelma) KISOR...OUR NEWEST ANGEL..HAS A REBIF TIP...ON GIVING YOURSELF A SHOT -stan Dec 22 2006 23:40
6 NEW! » WaterDragon SUPPORT ALERT QUESTION: "what have you heard about mono and ms? - shane Dec 24 2006 07:22
4 NEW! » David A GREAT STORY FROM MED STUDENT SOURCE: "New MS Therapies in Clinical Trials" Dec 24 2006 09:46
7 NEW! » David PERSEVERANCE IN TODAY'S NEWS Dec 24 2006 09:54
6 NEW! » David Romney has said he would end to his political career for his wife, who has MS. Dec 24 2006 10:00
1 NEW! » Luis TYSABRI SUPPORT ALERT: "Please help me Stan!" - JAMIE Dec 25 2006 06:29
4 NEW! » Lisa NEW STUDY ON MS & PREGNANCY Dec 25 2006 12:51
1 NEW! » Chanfb915 High Levels of Vitamin D In the Body May Decrease the Risk of MS: HARVARD PRESS RELEASE Dec 25 2006 18:29
3 NEW! » Mary and Robert ADD YOUR "HAPPY &/or FUNNY STORY" TO THE 31 BELOW: I'M GOING TO PUT THEM IN A SLIDESHOW - stan Dec 27 2006 00:46
1 NEW! » Mary and Robert SUPPORT ALERT UPDATE - 18 COMMENTS: "I am still trying to accept everything (dx Aug 2006)" Dec 27 2006 01:27
2 NEW! » Mary and Robert NEW PHOTOS-CONGRATS TO RENEE: "he popped the big question-he's seen me at my worse with my MS" Dec 27 2006 01:54
2 NEW! » Mary and Robert WELCOME sorormp3: OUR NEWEST Angel...A SUPER Stay-Home Mom and Retired Teacher Dec 27 2006 01:56
2 NEW! » Mary and Robert SUPPORT ALERT: "I'M DEPRESSED: Does anyone know anything about using chemo for MS?" - Valyum Dec 27 2006 01:59
1 NEW! » Mary and Robert OUR 17 YEAR OLD ANGEL ROSE GOT DIAMOND EARRINGS FOR XMAS: NICE BOYFRIEND! - stan Dec 27 2006 02:00
3 NEW! » Mary and Robert "I GOT A JOB OFFER STAN" - YVONNE Dec 27 2006 02:01
5 NEW! » Mary and Robert "a relationship suddenly breaking up. This happened last week-two days before my birthday." Dec 27 2006 02:12
8 NEW! » Mary and Robert "The greatest thing happened to me this past week at work!!!" - PATRICIA Dec 27 2006 02:15
1 NEW! » Mary and Robert "I wonder how I am going to be brave enough to self administer these injections? Dec 27 2006 02:24
4 NEW! » queen_racewife SUPPORT ALERT: "friends & family seem to be "backing off"-not sure how to "deal" with me & MS" Dec 27 2006 03:40
8 NEW! » queen_racewife WELCOME OUR NEWEST SUPPORT ANGEL: AMY Dec 27 2006 03:43
2 NEW! » queen_racewife SUPPORT ALERT: "i pray that i don't have a replapse while with family" - DIERDRE Dec 27 2006 04:03
4 NEW! » queen_racewife GREAT LONG STORY ON MY MAIN MS NEWS SITE - stan [too long 4 this blog] Dec 27 2006 04:05
5 NEW! » queen_racewife LADOSTIGIL (an Alzheimer's drug) for treating MS Dec 27 2006 04:17
3 NEW! » Gypsy Queen GOOD STORY ON EXERCISE FROM TODAY'S NEWS - stan Dec 27 2006 05:34
3 NEW! » Beth NATALIE'S PERSEVERANCE!!! YOUR COMMENTS OF SUPPORT HELPED NATALIE - stan Dec 27 2006 10:44
3 NEW! » David SUPPORT ALERT: "I HAD A MRI..IT SHOWED 1 NEW LESION FOR A TOTAL OF 10" - SUSAN Dec 27 2006 21:23
4 NEW! » David THIS IS A "INDEX OF STORIES" SLIDESHOW THAT IS UNDER CONSTUCTION: CAN U READ THE HEADLINES? Dec 27 2006 21:34
2 NEW! » Anne SUPPORT ALERT: My doctor says I may have MS & Fibromyalgia-does anyone else have both of these? Dec 28 2006 01:09
4 NEW! » HOOLIE 5 NEW TATS TODAY: "TATOOS AGAINST MS" Many have told me tatoos help them deal with MS Dec 28 2006 07:27
4 NEW! » Donna Mojo-"Athos" HAS A MOOD TIP: "I HAVE DAYS WHEN I'M SO LONELY THAT I SIT IN MY ROOM AND CRY" Dec 28 2006 10:25
1 NEW! » "Gamma Julie" SUPPORT ALERT FOR GENEISIS & HER "MS NIGHTS! DO U HAVE THE SAME PROBLEM? TELL US! - stan Dec 28 2006 02:58
1 NEW! » "Gamma Julie" COPAXONE SUPPORT ALERT: JULIE'S HUSBAND IS GETTING LUMPS LIKE A MARBLE @ THE INJECTION SITE!?? Dec 28 2006 03:12
2 NEW! » queen_racewife TYSABRI: HARVARD MED SCHOOL'S TOP 10 STORIES OF 2006 Dec 28 2006 05:28
10 NEW! » ~Ãngël~™ SUPPORT ALERT FOR SANDRA: "I AM SO STRESSED WITH THIS & DON'T KNOW WHAT TO DO" Dec 28 2006 07:49
10 NEW! » Jeannine 1,066 VISITORS & 152 COMMENTS ON OUR BLOG YESTERDAY - stan Dec 28 2006 08:02
6 NEW! » Key MS family's appearance on the ABC television show "Extreme Makeover: Home Edition" Dec 28 2006 12:13
15 NEW! » Katrina (great update: note from Kendra) SUPPORT ALERT: KENDRA NEEDS HUGS AND A NEW DOC!!! -stan Dec 28 2006 12:36
5 NEW! » Yvonne SUPPORT ALERT: "SINCE MY DX MY SEX LIFE HAS BEEN SHIT" DARTH WOKIE Dec 28 2006 12:46
3 NEW! » queen_racewife For kids, MS itself just half the battle: Correctly diagnosing disease can be tricky Dec 28 2006 12:59
15 NEW! » WaterDragon FATIGUE RELIEF: THIS IS ONE OF THE MOST IMPT POSTS I'VE MADE OUT OF 596 I'VE POSTED - stan Dec 28 2006 13:10
4 NEW! » Alpha [4 NEW ANGELS THIS AM] THESE 26 FRIENDS HAVE JOINED OUR 91 ANGELS OF SUPPORT THIS WEEK Dec 28 2006 14:13
16 NEW! » D SUPPORT ALERT FOR OUR NEWEST ANGEL-NANCY WHO HAS "WEIGHT GAIN OF 50 POUNDS" = stan Dec 28 2006 14:19
1 NEW! » Alpha SUPPORT ALERT: CANCER HASN'T STOPPED BRIAN'S WANTING TO BE AN "ANGEL OF SUPPORT" [HUGS! PLEASE]
From Subject Time Posted
1 NEW! » Jeannine Elan Extends Tysabri's Reach to Canada Oct 8 2006 07:46
1 NEW! » Jeannine 10 Top Australian Scientists Predict Major Medical Advances in MS (download free report) Oct 10 2006 13:11
1 NEW! » Jeannine NEUROVAX: PRESS RELEASE FROM IMMUNE RESPONSE CORP. Oct 10 2006 13:06
1 NEW! » "Gamma Julie" Should Job Hunters Reveal Chronic Illness? The Pros and Cons..[update] Oct 31 2006 03:41
1 NEW! » Jeannine HUMAN STEM CELLS DELAY START OF LOU GEHRIG'S DISEASE IN RATS Oct 15 2006 10:02
1 NEW! » Jeannine Tysabri and Avonex add customer service reps Oct 17 2006 07:34
1 NEW! » Jeannine "Take 10 laps and call me in the morning" Oct 17 2006 09:15
1 NEW! » Jeannine "inmate moved to hospital" (AN UPDATE OF LAST WEEKS STORY: "INMATE WITH MS" Oct 17 2006 09:42
1 NEW! » Jeannine Fampridine SR - NEW DRUG IN PIPELINE Oct 18 2006 09:42
1 NEW! » Jeannine [PROFESSIONAL ABSTRACT] Oct 18 2006 09:43
1 NEW! » David "Copaxone allows some MS patients to retain mobility" Oct 19 2006 19:50
1 NEW! » Lora Future-directed thinking and depression in MS [READ LIZZY'S COMMENT!!!] Oct 28 2006 15:03
1 NEW! » Jeannine MS BIKE TREK Oct 19 2006 09:38
1 NEW! » WaterDragon STEM CELL: "Federal government promotes donation of umbilical cords for stem cell transplants" Oct 20 2006 00:51
1 NEW! » Jeannine Development of an anti-IL-17A auto-vaccine... Oct 20 2006 09:05
1 NEW! » Jeannine GREAT PERSONAL STORY: Oct 20 2006 15:17
1 NEW! » Jeannine "Acute leukaemia in two multiple sclerosis patients treated with mitoxantrone" Oct 20 2006 15:21
1 NEW! » Jeannine The Effect of dose and frequency of interferon beta-1a administration Oct 20 2006 15:31
1 NEW! » Jeannine CDP323: NEW DRUG IN PIPLINE Oct 21 2006 09:58
1 NEW! » Jeannine Did you know that Colorado has one of the highest prevalence rates of MS in the US Oct 21 2006 09:59
1 NEW! » Jeannine Write in Candidate Denise Clement will work for free! Oct 21 2006 10:00
1 NEW! » Jeannine Methylthioadenosine Effective in Animal Models of Multiple Sclerosis Oct 22 2006 07:32
1 NEW! » Jeannine UK: cannabis pill test Oct 22 2006 07:34
1 NEW! » Jeannine Clustering of autoimmune diseases in families with a high-risk for MS: Oct 23 2006 07:36
1 NEW! » Jeannine The female to male sex ratio by year of birth has been increasing for at least 50 years Oct 23 2006 07:39
1 NEW! » Jeannine Photography studio is donating fees to MS Oct 23 2006 08:17
1 NEW! » Jeannine Boston Home's 125th Anniversary - Oct 24 2006 09:28
1 NEW! » Jeannine UK...MP's Back MS Campaign Oct 24 2006 09:32
1 NEW! » Jeannine Dutch prosecutors ask highest court to quash appeals court medicinal cannabis decision Oct 24 2006 09:34
1 NEW! » Jeannine MBP8298 Oct 24 2006 09:35
1 NEW! » deleted account Live HealthTalk - 30 Minutes of Q&A with Nurse Piper [sponsored by a drug company] Oct 24 2006 19:50
1 NEW! » Jeannine High-Dose Cyclophosphamide Study: GOOD RESULTS!!! Oct 25 2006 09:32
1 NEW! » Jeannine NEW DRUG IN PIPELINE: MCT-125 Oct 25 2006 09:35
1 NEW! » Jeannine 3 Guys, 3 Bikes, 7,000 Miles Through South America for MS Oct 25 2006 09:39
1 NEW! » Jeannine 14-year old bicyclist rides for MS Oct 26 2006 08:24
1 NEW! » Jeannine Accelerated Cure Project for MS today announced the formation of their MS Repository Oct 26 2006 08:29
1 NEW! » Jeannine A MSnewsChannel.com Video: A TIP FROM HEATHER ON EASING REBIF PAIN Oct 26 2006 09:02
1 NEW! » Jeannine TYSABRI® GOOD FOR LUPUS TOO...PER THIS PRESS RELEASE FROM ELAN Oct 26 2006 09:04
1 NEW! » Jeannine VISIT OUR "TYSABRI NEWS" WEBSITE Oct 26 2006 09:08
1 NEW! » Jeannine Joseph Eisen suffers from Primary Progressive Multiple Sclerosis....AGENGY HELPS WITH HIS LEGAL Oct 27 2006 08:18
1 NEW! » Jeannine Campus Fudraiser....(good idea for other colleges) Oct 27 2006 14:22
1 NEW! » David WATCH VIDEO: Selling CDs as a MS Fundraiser Oct 29 2006 09:03
1 NEW! » Jeannine If a sibling has MS, you are 15 to 25 times more likely to develop it yourself Oct 29 2006 09:16
1 NEW! » Jeannine UK: NO JAIL FOR HUSBAND WHO HELPED WIFE'S SUICIDE Oct 29 2006 09:18
1 NEW! » Jeannine Car enthusiasts, bikers rally MS Oct 29 2006 09:26
1 NEW! » Jeannine UPDATE ON MS CANDIDATE WHOSE OPPONENT MADE A NASTY WHEELCHAIR COMMENT Oct 30 2006 08:32
2 NEW! » Jeannine "MS NO LONGER A DEATH KNELL FOR PATIENTS" Oct 30 2006 08:43
2 NEW! » David WATCH VIDEO PLUS FREE READ OF CHAPTER 1 : Today show host Meredith Vieira talks with Teri Garr Oct 30 2006 20:27
1 NEW! » WaterDragon "Ed Johns says he feels like a new man" [I WOULDN'T LET MY SON DO THIS!-stan] Oct 31 2006 01:11
1 NEW! » Jeannine TYSABRI.....Biogen Idec Third-Quarter Net Rises Sixfold on MS Drugs Oct 31 2006 09:18
1 NEW! » Jeannine DETROIT FUNDRAISER Nov 1 2006 10:08
1 NEW! » Jeannine ABSTRACT FOR DOCS, NURSES Nov 1 2006 10:09
2 NEW! » Jeannine .....control of their health with exercise, even though it might bring short-term discomfort Nov 1 2006 15:05
1 NEW! » Darth Woky ™ GREAT READ: MS afflicts about twice as many females as males Nov 2 2006 01:15
2 NEW! » David Cladribine used to treat some cancers and possibly MS: Brigham Young University Nov 2 2006 19:15
2 NEW! » David I JUST RECEIVED THIS PRESS RELEASE FROM TEVA RE: COPAXONE {NOT IMPORTANT :-)] Nov 2 2006 19:23
2 NEW! » David VOTE: ANOTHER STEM CELL STORY(I can't decide if I should post stem cell stories or not?? -stan) Nov 2 2006 19:33
3 NEW! » David update: DRUG DELAYED BY FDA FOR A MS CONDITION I'VE NOT HEARD OF -HAVE YOU??? -stan Nov 2 2006 19:36
2 NEW! » David MS Linked to Abnormal Liver Test Results Nov 2 2006 19:46
1 NEW! » Rev. cutthroat carnie TYSABRI BAD NEWS:Since July, only 47 of more than 8,500 patients are using Tysabri... Nov 7 2006 08:13
1 NEW! » Jeannine New York City Chapter MS Society: Help Us Reach Our Fundraising Goal for the MS Bike Tour Nov 1 2006 14:43
1 NEW! » Jeannine BAD NEWS ON UCLA PLAYER WE HAVE BEEN REPORTING ON Nov 2 2006 08:27
1 NEW! » Jeannine !!!...Fampridine-SR: WONDERFUL TRIAL RESULTS ON NEW DRUG Nov 2 2006 08:29
2 NEW! » queen_racewife PRESS RELEASE ON NEW DRUG: MBP8298 [TRIALS ARE VERY GOOD OUT OF THE US!!!] Nov 2 2006 08:35
1 NEW! » Mary and Robert GREAT STORY OF PERSEVERANCE Nov 2 2006 10:40
1 NEW! » Jeannine Study sheds light on myelination Nov 3 2006 07:04
1 NEW! » Jeannine FDA Approvals: Interferon-beta-1b (Betaseron) for Use in Early Multiple Sclerosis Nov 3 2006 18:13
1 NEW! » "Gamma Julie" 'miracle drug' is supposedly no good Nov 4 2006 02:01
2 NEW! » Roseanne ENVIRONMENT CAUSE OF WOMEN'S HIGHER RISK OF MS? Nov 4 2006 09:05
1 NEW! » Jeannine cladrabine Nov 4 2006 14:09
2 NEW! » Jeannine MS Society's 'Shining Star Nov 4 2006 14:30
1 NEW! » Jeannine NEW DRUG IN PIPELINE: MBP8298 Nov 4 2006 14:33
3 NEW! » David UK - EXPERTS believe they have discovered a protein which could help create new MS treatments Nov 4 2006 18:14
1 NEW! » Jeannine WONDERFUL STORY OF PERSEVERANCE IN THIS SUNDAY'S NYC MARATHON Nov 5 2006 12:08
1 NEW! » ~Ãngël~™ NPR AUDIO: Studies have found that a six-month Iyengar yoga program helped people with MS comba Nov 5 2006 17:35
2 NEW! » Jeannine "advances on the horizon..." Nov 6 2006 09:12
1 NEW! » Jeannine GREAT ADVICE FOR CAREGIVERS - stan Nov 6 2006 09:28
2 NEW! » Darth Woky ™ (UPDATE ON THIS STORY IS AB0VE) CHURCHILL DOWNS PERSEVERANCE Nov 7 2006 01:22
2 NEW! » "Gamma Julie" Award given to Scott Johnson, President and Founder of the Myelin Repair Foundation Nov 7 2006 04:46
2 NEW! » queen_racewife INTERESTING IMPLANT STUDY....update Nov 8 2006 03:38
1 NEW! » David (READ THE GREAT COMMENTS) TOVAXIN...NEW MS DRUG IN PIPELINE STARTS DOSING Nov 9 2006 22:56
2 NEW! » Lora GOOD INTERVIEW WITH AUTHOR OF NEW BOOK: ABOUT HER MS Nov 10 2006 13:39
2 NEW! » Mary and Robert Man says tai chi gave him second chance at life. Nov 10 2006 17:20
3 NEW! » Jeannine oral Trimesta (estriol)...A NEW MS DRUG IN THE PIPELINE!!!!! [UPDATE] Nov 10 2006 18:54
1 NEW! » Jeannine STORY OF 37-YEAR OLDS PERSEVERANCE Nov 10 2006 19:00
1 NEW! » Jeannine NEW BROCHURE: Volunteering for a Clinical Trial: Your Guide to Participating in a Trial Nov 10 2006 19:01
1 NEW! » Jeannine ECCO Shoes Plans to Donates $2 Per Pair of Shoes Sold to MS [good idea for US] Nov 10 2006 19:08
1 NEW! » Jeannine 58% of long-term care claimants are younger than 65 and the top five claims causes are MS, Canc Nov 10 2006 19:09
3 NEW! » Jeannine "Advances on the horizon in treating and curing MS" Nov 10 2006 19:15
1 NEW! » Jeannine A medical marijuana ballot in South Dakota Today Nov 10 2006 19:17
1 NEW! » Jeannine study identifies how treatment can limit impact of T-cells in autoimmune diseases Nov 10 2006 19:19
1 NEW! » Jeannine MS fundraising luncheon in Ne Jersey Nov 10 2006 19:19
1 NEW! » Jeannine Treatment of neuropsychiatric conditions associated with MS Nov 10 2006 19:21
1 NEW! » Jeannine BREEDERS CUP WIN! McLaughlin on his battle with MS (THE STORY ON THIS FROM LAST WEEK IS BELOW) Nov 10 2006 19:23
1 NEW! » Jeannine PERSEVERANCE: PAT KINSLEY GIVE BACK TO KIDS Nov 10 2006 19:27
1 NEW! » Jeannine GREAT AND IMPORTANT STORY ABOUT DOGS AS HELPERS FOR MS PATIENTS - stan Nov 10 2006 19:28
2 NEW! » Jeannine FDA APPROVAL: BETASERON UPDATE Nov 10 2006 19:30
2 NEW! » Jeannine ELK HUNTING & MS STORY Nov 10 2006 19:32
2 NEW! » Jeannine B12 and MS: UK MS SOCIETY EDITORIAL Nov 10 2006 19:33
3 NEW! » Mary and Robert Help fight multiple sclerosis with me - The Bakersfield Voice Nov 11 2006 02:06
2 NEW! » Mary and Robert {PERSEVERANCE}.....Cheri Piekarski's job is a labor of love Nov 11 2006 13:41
1 NEW! » Jeannine MARY MOLDS' MS DOESN'T STOP HER FROM HELPING OTHERS Nov 12 2006 08:05
3 NEW! » ♥Debbie♥ GOOD WHEELCHAIR NEWS: Battle over Payments Cuts by CMS is being won!!!! Nov 13 2006 08:24
3 NEW! » David "I believe that a person who can't read in our society is more handicapped than I am," Merens s Nov 13 2006 20:35
2 NEW! » Key two-headed snake Nov 13 2006 20:42
2 NEW! » MRSMUSTAINE NEW PATENTS FOR MS MED Nov 14 2006 02:08
1 NEW! » "Gamma Julie" Cannabis Study in news this AM Nov 15 2006 01:39
1 NEW! » "Gamma Julie" memory study Nov 15 2006 01:52
3 NEW! » "Gamma Julie" "Research Highlights" from the New York City Chapter of the National Multiple Sclerosis Society Nov 15 2006 01:59
1 NEW! » "Gamma Julie" GREAT ARTICLE...THINGS ABOUT RICHARD PRYOR & HIS DAUGHTER RAIN THAT HAVE NEVER BEEN TOLD!-stan Nov 15 2006 02:17
1 NEW! » "Gamma Julie" GETTING TOUGH ON MEDICINAL POT SELLERS Nov 15 2006 02:29
1 NEW! » queen_racewife SAMANTHA..PERSEVERANCE AND KINDNESS AT 15 YEARS OLD...."SHE IS MY REAL HERO"-stan Nov 15 2006 17:28
2 NEW! » queen_racewife BNC105: PRESS RELEASE ON THIS NEW DRUG IN PIPLINE Nov 15 2006 17:42
4 NEW! » queen_racewife STEM CELL STORY FROM THE UK Nov 15 2006 17:47
1 NEW! » David "laughing and intractable hiccups can occur early in MS" [study] Nov 16 2006 20:02
4 NEW! » David New Wave Of HOPE- Support Group Aims To Aid MS Patients Nov 17 2006 20:25
2 NEW! » David Amy Clawson: Country music artist Nov 17 2006 20:32
1 NEW! » David TYSABRI: Natalizumab Alters T Cell Ratio in MS Patients (Reuters Health) Nov 19 2006 10:09
2 NEW! » Alpha [GREAT READ] Geographical disparity of Diseases Nov 19 2006 18:55
1 NEW! » Jenn MBP8298: NEW DRUG IN PIPELINE Nov 19 2006 20:13
4 NEW! » Jenn ANOTHER CRAZY STORY FROM THE UK: "FREEZE TREATMENT FOR MS" Nov 19 2006 20:24
1 NEW! » Tim Foolery There are a lot of new things in Krystal Hexamer's life: Research Promises New Treatment for MS Nov 20 2006 07:38
4 NEW! » Stacey OUR FRIEND LARRY NEEDS YOUR HELP: BOTH HE AND HIS MOM HAVE MS Nov 24 2006 07:56
3 NEW! » Shell THIS IS WHY I LOVE MySpace...AND MY MySpace FRIENDS - stan Nov 24 2006 11:36
1 NEW! » Mary and Robert Wheelchair bowlers still rolling Nov 18 2006 16:53
1 NEW! » David THIS POST CAME FROM OUR CORRESPONDENT ANNE: A SIMPLE TEST FOR MS Nov 19 2006 10:27
1 NEW! » Darth Woky ™ CLEVELAND CLINIC TIPS ON: STRESS AND MS Nov 20 2006 01:35
3 NEW! » ♥Debbie♥ "FAMOUS PATIENTS AND THE LESSONS THEY TEACH"...THE NEW YORK TIMES Nov 20 2006 05:11
4 NEW! » Tim Foolery Stem cells might cause brain tumors Nov 20 2006 07:22
1 NEW! » WaterDragon {READ THIS!!!-stan} DRUG COMBO SHOWS SHOCKING REVERSAL OF MS SYMPTOMS Nov 21 2006 04:36
1 NEW! » WaterDragon "What if we could actually reverse the damage that MS causes, restoring function..." Nov 21 2006 05:10
1 NEW! » Jeannine Stada said it is no longer to pursue its Interferon-beta project to treat MS Nov 21 2006 07:28
4 NEW! » Shell Clinical Trial Design Nov 22 2006 07:48
4 NEW! » Alpha STUDY FINISHED RE: people's concern about a perceived high rate of MS in Illinois cities Nov 22 2006 11:20
5 NEW! » David New Patent for diagnosing MS Nov 22 2006 13:17
1 NEW! » Roseanne GREAT EXPLANATION OF STEM CELLS AND THEIR POSSIBLE USE IN MS Nov 23 2006 07:37
2 NEW! » Alpha PERSONAL STORY OF THANKSGIVING Nov 23 2006 20:52
3 NEW! » Alpha SOUTH FLORIDA - National MS Health Expo Is November 19th Nov 24 2006 17:06
4 NEW! » Jeannine YOUR COMMENTS HAVE HELPED "FOOL ON THE HILL"...stan Nov 24 2006 19:00
3 NEW! » "Gamma Julie" {first time i've seen a charity benefit solely for low income ms patients-stan} Nov 25 2006 07:08
5 NEW! » Mary and Robert Multiple Sclerosis Society Alert re: funding Nov 25 2006 23:44
3 NEW! » Mary and Robert DACLIZUMAB FOR MS Nov 25 2006 23:46
4 NEW! » queen_racewife GOOD STORY - University of Rochester presses quest for stem cell breakthrough Nov 26 2006 10:50
5 NEW! » Alpha [WOW!!! READ THIS!!-stan] High-tech device helps a martial artist learn how to walk again Nov 26 2006 16:18
2 NEW! » Kendra OUR FRIEND KENDRA NEEDS OUR WISHES OF GOOD LUCK! HER SURGERY IS APPROACHING - stan Nov 27 2006 08:17
5 NEW! » Alpha Results of study on prevalence of MS in Lewistown to be presented Nov 28 2006 08:36
2 NEW! » ♥Debbie♥ "Do you believe in miracles? " By Linda Beck Nov 28 2006 10:02
1 NEW! » ♥Debbie♥ OUR FRIEND AND "STAR COMMENTATOR" KEY HAS GOOD NEWS Nov 28 2006 10:06
3 NEW! » ♥Debbie♥ THIS IS GREAT: FREE BOOKLET FROM THE UK Nov 28 2006 10:14
1 NEW! » ~♥sweet caroline♥~ OUR FRIEND DEBBIE NEEDS A HUG! SHE HAS A MESSAGE FOR EVERYONE Nov 28 2006 21:01
1 NEW! » Francine MS Holiday Gift Guide Nov 29 2006 08:07
8 NEW! » David "Glatiramer acetate therapy for multiple sclerosis" Nov 29 2006 19:30
1 NEW! » David DARTH WOKY: ONE OF MY BEST FRIENDS NEEDS YOUR ADVICE Dec 2 2006 12:38
3 NEW! » ♥Debbie♥ [update-18 comments] JENNIFER NEEDS SUPPORT: "MY LEGS ARE STIFF & LIFELESS" Dec 4 2006 08:14
2 NEW! » Anne SAD STORY FROM TODAYS HEADLINES Dec 5 2006 05:06
4 NEW! » Anne MELISSA NEEDS SUPPORT Dec 5 2006 05:32
2 NEW! » Kendra NO MERCURY RISK IN AMALGAM FILLINGS Dec 5 2006 08:16
2 NEW! » queen_racewife KIDS: "Why are our children's bodies attacking them? Dec 6 2006 02:55
4 NEW! » queen_racewife PERSEVERANCE: GREAT STORY Dec 6 2006 03:07
1 NEW! » queen_racewife HIGH INCIDENCE OF MS IN ILLINOIS TOWN PUZZLES RESEARCHERS Dec 6 2006 03:23
5 NEW! » queen_racewife PERSEVERANCE: GREAT RADIO INTERVIEW Dec 6 2006 03:35
2 NEW! » Shell PERSEVERANCE...Susan Greenop"s personal story Dec 6 2006 04:49
7 NEW! » Alpha STEM CELL STUDY Dec 6 2006 09:32
3 NEW! » (¯`•´¯)Starr(¯`•´¯) ARTISTS FOR MS Dec 6 2006 09:53
8 NEW! » Mich/Neurotrash'd TERI GARR Dec 7 2006 10:18
1 NEW! » Sean GREAT DISCOVERY AT STANFORD MED SCHOOL: Molecule Linked to Autoimmune Disease Relapses Found Dec 8 2006 15:54
2 NEW! » Mary and Robert GIVE CONGRATS TO TIM FOOLERY FOR GETTING A RAISE! Dec 8 2006 19:12
8 NEW! » David Prescription for the Soul Dec 8 2006 21:07
7 NEW! » Alpha GREAT NEW DRUG: Fampridine-SR Dec 9 2006 12:05
7 NEW! » (¯`•´¯)Starr(¯`•´¯) DISABLED STILL FACE OBSTACLES Dec 9 2006 14:31
5 NEW! » Rev UPDATE ON POT IN CANDY BARS FROM YESTERDAY Dec 10 2006 10:57
4 NEW! » ~Ãngël~™ UPDATE: 36 COMMENTS- ADD YOUR STORY & SHARE YOUR ADVICE: MS IS INTERFERING IN ANGEL'S LOVE LIFE Dec 10 2006 11:16
1 NEW! » Wendy SENATE PASSES GREAT NEW BILL FOR MS Dec 11 2006 08:04
5 NEW! » Tim Foolery "Activists are convinced that electrical pollution is making us sick" Dec 11 2006 09:31
6 NEW! » Tim Foolery GREAT STORY OF PERSEVERANCE FROM TODAY'S HEADLINES Dec 11 2006 09:32
1 NEW! » Tim Foolery CONGRATS TO LORA: SHE'S ALMOST DONE WITH LAW SCHOOL Dec 11 2006 09:33
6 NEW! » Tim Foolery A happy fundraising story - stan Dec 11 2006 14:29
2 NEW! » Jenn CONGRATS TO JENN: "I found out last Monday that hubby and I are expecting .2" Dec 11 2006 18:50
7 NEW! » Yvonne UPDATE ON YESTERDAYS TYSABRI STORY: "1000 MS PATIENTS REFUSED TYSABRI: IT COSTS TOO MUCH! Dec 12 2006 06:54
3 NEW! » Renee JILL'S BDAY IS TODAY...PLUS CONGRATS TO HER ON GRAD SCHOOL!! - stan Dec 13 2006 09:43
1 NEW! » WaterDragon 2 IMPORTANT NEW STUDIES ON GRAY MATTER DAMAGE IN MS Dec 14 2006 04:50
6 NEW! » Alpha MS FAMILY BATTLES LYME DISEASE Dec 14 2006 12:14
1 NEW! » Patti (aka Thelma) UPDATE ON MY POST FROM DECEMBER 4TH: "SIF IS GETTING CHEMO TOMORROW" Dec 14 2006 23:18
4 NEW! » Jeannine TYSABRI: RICH WANTS TO TAKE IT ...BUT HAS A QUESTION Dec 15 2006 07:02
5 NEW! » ~Ãngël~™ GREAT STORY ON NEW JERSEY BIKE TEAM Dec 15 2006 09:44
3 NEW! » ~♥sweet caroline♥~ SUPPORT TEAM ALERT: ANGEL HAS HELPED MANY OTHERS-NOW SHE NEEDS OUR SUPPORT - stan Dec 15 2006 16:08
3 NEW! » CARRIE AMAZING NEWS! CONGRATS TO EVERYONE WHO HAS BEEN MAKING COMMENTS! LOOK AT THIS INFO: Dec 15 2006 20:55
7 NEW! » David CONTROVERSIAL CLINIC SHUT DOWN Dec 15 2006 21:40
7 NEW! » Mary and Robert SAD STORY ABOUT JAZZ SINGER Dec 16 2006 14:58
2 NEW! » David "1000 PATIENTS IN THE UK TO BE DENIED TYSABRI: NOT COST EFFECTIVE" Dec 17 2006 12:25
1 NEW! » David BILLY TALLENT: one of my fav bands [my favorite is Hatebreed] - stan Dec 17 2006 13:37
5 NEW! » Jeannine A MESSAGE FROM ONE OF OUR SUPPORT ANGELS: ALPHA...WHO IS STRANDED IN SEATTLE! -stan Dec 18 2006 14:37
4 NEW! » Jeannine TYSABRI FOR CROHN'S DISEASE TOO!!!! Dec 18 2006 14:40
1 NEW! » Jeannine GREAT NEWS ON NEW MS DRUG FOR MS FATIGUE: MCT-125 Dec 18 2006 14:40
5 NEW! » Jeannine GIVE SPHILLY CONGRATS ON GETTING APPROVED FOR A GRANT Dec 18 2006 14:42
6 NEW! » Jeannine "HAPPY NEWS" FROM OUR SUPPORT ANGEL ANNE - stan Dec 18 2006 14:44
2 NEW! » Jeannine SUPPORT GROUP ALERT: I HAVE RECEIVED MANY EMAILS THIS WEEK FROM OUR FRIENDS WHO ARE SAD Dec 18 2006 14:46
3 NEW! » WaterDragon SUPPORT ALERT: "i have been just feeling like why me why did i have to have ms!" - TERI Dec 18 2006 16:57
4 NEW! » SPhilly SUPPORT ALERT: GIVE RainMaker A PAT ON THE BACK FOR STARTING HIS MS TREATMENT - stan Dec 18 2006 22:30
2 NEW! » Darth Woky ™ CONGRATS TO OUR ANGELS OF SUPPORT: YOUR ADVICE HELPED Holy Crip Dec 19 2006 01:32
4 NEW! » <3i data-blogger-escaped--="" data-blogger-escaped-09:57="" data-blogger-escaped-19="" data-blogger-escaped-2006="" data-blogger-escaped-at="" data-blogger-escaped-br="" data-blogger-escaped-coming="" data-blogger-escaped-dec="" data-blogger-escaped-drug="" data-blogger-escaped-glass="" data-blogger-escaped-great="" data-blogger-escaped-looking="" data-blogger-escaped-m="" data-blogger-escaped-new="" data-blogger-escaped-oral="" data-blogger-escaped-soon...hopefully="" data-blogger-escaped-stan="" data-blogger-escaped-the="" data-blogger-escaped-through="" data-blogger-escaped-you="">1 NEW! » (¯`•´¯)Starr(¯`•´¯) 1,039 FRIENDS VISITED OUR BLOG YESTERDAY & READ YOUR 125 COMMENTS!!!!!!!!!!! - stan Dec 19 2006 10:15
4 NEW! » (¯`•´¯)Starr(¯`•´¯) TERI & ALPHA THINK THIS STORY WILL HELP EXPLAIN MS TO YOUR FAMILY: IT'S ALSO ON TYSABRI - stan Dec 19 2006 10:20
1 NEW! » Melissa NEW PAIN DRUG APPROVED FOR MS...IN EUROPE...WHICH MEANS IT WILL HOPEFULLY BE HERE SOON - stan Dec 19 2006 15:10
4 NEW! » Kim SUPPORT ALERT: BOTH SUSAN AND I NEED HELP! - stan Dec 19 2006 19:33
9 NEW! » Jeannine HAPPY HOLIDAY STORY IN TODAY' NEWS -stan Dec 20 2006 09:55
2 NEW! » Jeannine GIVE CHRIS...OUR NEWSEST ANGEL OF SUPPORT A HUG - stan Dec 20 2006 10:05
4 NEW! » Jeannine POSSIBLE NEW MS TREATMENT: SOY!!!!!!!!!!!!!!!! Dec 20 2006 10:27
5 NEW! » Jeannine INTERESTING STUDY ON RURAL VS URBAN USE OF DOCTORS IN MS PATIENTS Dec 20 2006 10:30
4 NEW! » Jeannine DIABETES BREATHROUGH - RELATIONSHIP TO MS? SEE MY POST ABOVE FROM VIVIAN Dec 20 2006 10:34
1 NEW! » Jeannine AN INTERESTING EMAIL ON DIABETES CURE AND I'S RELATION TO MS Dec 20 2006 10:35
7 NEW! » David THIS STORY IS BETTER THAN THE TRASH FICTION BOOKS I LOVE TO READ - stan Dec 20 2006 20:21
6 NEW! » David NEW MS DRUG UPDATE IN THE NEWS: CHR-1103 Dec 20 2006 20:23
4 NEW! » David UPDATE: FDA ADVISORY (WARNING) 2 Rituxan deaths: of Tysabri type..rare brain infection Dec 20 2006 20:30
7 NEW! » There Can Only Be One Me SUPPORT ALERT FOR FRANCINE - SHE HAS HELPED MANY FRIENDS - NOW SHE NEEDS HUGS! - stan Dec 21 2006 06:58
2 NEW! » Jeannine COGNITIVE TRAINING HELPS SENIORS" [STUDY] MAYBE IT WILL HELP MS TOO??? Dec 21 2006 06:59
1 NEW! » Miss Kitty MY MESSAGE TO OUR ANGELS OF SUPPORT- RE: YOUR 2 HOLIDAY GIFTS FROM ME + HELP 4 FRIENDS -stan Dec 21 2006 11:10
7 NEW! » :Vitamin DEE: STORY ON NEW MS DRUG IN THE PIPELINE: NEUROVAX Dec 21 2006 21:31
3 NEW! » queen_racewife READ 42 COMMENTS-MARIES IMPORTANT UPDATE ON HER Dec 22 2006 05:43
2 NEW! » (¯`•´¯)Starr(¯`•´¯) DEBBIE'S CHRISTMAS MESSAGE TO OUR Angels of Support Dec 22 2006 10:03
7 NEW! » (¯`•´¯)Starr(¯`•´¯) GREAT STORY OF A MED STUDENT'S PERSEVERANCE IN TODAYS HEADLINE NEWS - stan Dec 22 2006 10:20
7 NEW! » Anne ANOTHER SUCCESS FOR OUR Angel of Support KELLI'S VIDEO - stan Dec 22 2006 16:55
1 NEW! » Patti (aka Thelma) KISOR...OUR NEWEST ANGEL..HAS A REBIF TIP...ON GIVING YOURSELF A SHOT -stan Dec 22 2006 23:40
6 NEW! » WaterDragon SUPPORT ALERT QUESTION: "what have you heard about mono and ms? - shane Dec 24 2006 07:22
4 NEW! » David A GREAT STORY FROM MED STUDENT SOURCE: "New MS Therapies in Clinical Trials" Dec 24 2006 09:46
7 NEW! » David PERSEVERANCE IN TODAY'S NEWS Dec 24 2006 09:54
6 NEW! » David Romney has said he would end to his political career for his wife, who has MS. Dec 24 2006 10:00
1 NEW! » Luis TYSABRI SUPPORT ALERT: "Please help me Stan!" - JAMIE Dec 25 2006 06:29
4 NEW! » Lisa NEW STUDY ON MS & PREGNANCY Dec 25 2006 12:51
1 NEW! » Chanfb915 High Levels of Vitamin D In the Body May Decrease the Risk of MS: HARVARD PRESS RELEASE Dec 25 2006 18:29
3 NEW! » Mary and Robert ADD YOUR "HAPPY &/or FUNNY STORY" TO THE 31 BELOW: I'M GOING TO PUT THEM IN A SLIDESHOW - stan Dec 27 2006 00:46
1 NEW! » Mary and Robert SUPPORT ALERT UPDATE - 18 COMMENTS: "I am still trying to accept everything (dx Aug 2006)" Dec 27 2006 01:27
2 NEW! » Mary and Robert NEW PHOTOS-CONGRATS TO RENEE: "he popped the big question-he's seen me at my worse with my MS" Dec 27 2006 01:54
2 NEW! » Mary and Robert WELCOME sorormp3: OUR NEWEST Angel...A SUPER Stay-Home Mom and Retired Teacher Dec 27 2006 01:56
2 NEW! » Mary and Robert SUPPORT ALERT: "I'M DEPRESSED: Does anyone know anything about using chemo for MS?" - Valyum Dec 27 2006 01:59
1 NEW! » Mary and Robert OUR 17 YEAR OLD ANGEL ROSE GOT DIAMOND EARRINGS FOR XMAS: NICE BOYFRIEND! - stan Dec 27 2006 02:00
3 NEW! » Mary and Robert "I GOT A JOB OFFER STAN" - YVONNE Dec 27 2006 02:01
5 NEW! » Mary and Robert "a relationship suddenly breaking up. This happened last week-two days before my birthday." Dec 27 2006 02:12
8 NEW! » Mary and Robert "The greatest thing happened to me this past week at work!!!" - PATRICIA Dec 27 2006 02:15
1 NEW! » Mary and Robert "I wonder how I am going to be brave enough to self administer these injections? Dec 27 2006 02:24
4 NEW! » queen_racewife SUPPORT ALERT: "friends & family seem to be "backing off"-not sure how to "deal" with me & MS" Dec 27 2006 03:40
8 NEW! » queen_racewife WELCOME OUR NEWEST SUPPORT ANGEL: AMY Dec 27 2006 03:43
2 NEW! » queen_racewife SUPPORT ALERT: "i pray that i don't have a replapse while with family" - DIERDRE Dec 27 2006 04:03
4 NEW! » queen_racewife GREAT LONG STORY ON MY MAIN MS NEWS SITE - stan [too long 4 this blog] Dec 27 2006 04:05
5 NEW! » queen_racewife LADOSTIGIL (an Alzheimer's drug) for treating MS Dec 27 2006 04:17
3 NEW! » Gypsy Queen GOOD STORY ON EXERCISE FROM TODAY'S NEWS - stan Dec 27 2006 05:34
3 NEW! » Beth NATALIE'S PERSEVERANCE!!! YOUR COMMENTS OF SUPPORT HELPED NATALIE - stan Dec 27 2006 10:44
3 NEW! » David SUPPORT ALERT: "I HAD A MRI..IT SHOWED 1 NEW LESION FOR A TOTAL OF 10" - SUSAN Dec 27 2006 21:23
4 NEW! » David THIS IS A "INDEX OF STORIES" SLIDESHOW THAT IS UNDER CONSTUCTION: CAN U READ THE HEADLINES? Dec 27 2006 21:34
2 NEW! » Anne SUPPORT ALERT: My doctor says I may have MS & Fibromyalgia-does anyone else have both of these? Dec 28 2006 01:09
4 NEW! » HOOLIE 5 NEW TATS TODAY: "TATOOS AGAINST MS" Many have told me tatoos help them deal with MS Dec 28 2006 07:27
4 NEW! » Donna Mojo-"Athos" HAS A MOOD TIP: "I HAVE DAYS WHEN I'M SO LONELY THAT I SIT IN MY ROOM AND CRY" Dec 28 2006 10:25
1 NEW! » "Gamma Julie" SUPPORT ALERT FOR GENEISIS & HER "MS NIGHTS! DO U HAVE THE SAME PROBLEM? TELL US! - stan Dec 28 2006 02:58
1 NEW! » "Gamma Julie" COPAXONE SUPPORT ALERT: JULIE'S HUSBAND IS GETTING LUMPS LIKE A MARBLE @ THE INJECTION SITE!?? Dec 28 2006 03:12
2 NEW! » queen_racewife TYSABRI: HARVARD MED SCHOOL'S TOP 10 STORIES OF 2006 Dec 28 2006 05:28
10 NEW! » ~Ãngël~™ SUPPORT ALERT FOR SANDRA: "I AM SO STRESSED WITH THIS & DON'T KNOW WHAT TO DO" Dec 28 2006 07:49
10 NEW! » Jeannine 1,066 VISITORS & 152 COMMENTS ON OUR BLOG YESTERDAY - stan Dec 28 2006 08:02
6 NEW! » Key MS family's appearance on the ABC television show "Extreme Makeover: Home Edition" Dec 28 2006 12:13
15 NEW! » Katrina (great update: note from Kendra) SUPPORT ALERT: KENDRA NEEDS HUGS AND A NEW DOC!!! -stan Dec 28 2006 12:36
5 NEW! » Yvonne SUPPORT ALERT: "SINCE MY DX MY SEX LIFE HAS BEEN SHIT" DARTH WOKIE Dec 28 2006 12:46
3 NEW! » queen_racewife For kids, MS itself just half the battle: Correctly diagnosing disease can be tricky Dec 28 2006 12:59
15 NEW! » WaterDragon FATIGUE RELIEF: THIS IS ONE OF THE MOST IMPT POSTS I'VE MADE OUT OF 596 I'VE POSTED - stan Dec 28 2006 13:10
4 NEW! » Alpha [4 NEW ANGELS THIS AM] THESE 26 FRIENDS HAVE JOINED OUR 91 ANGELS OF SUPPORT THIS WEEK Dec 28 2006 14:13
16 NEW! » D SUPPORT ALERT FOR OUR NEWEST ANGEL-NANCY WHO HAS "WEIGHT GAIN OF 50 POUNDS" = stan Dec 28 2006 14:19
1 NEW! » Alpha SUPPORT ALERT: CANCER HASN'T STOPPED BRIAN'S WANTING TO BE AN "ANGEL OF SUPPORT" [HUGS! PLEASE]
TYSABRI: HARVARD MED SCHOOL'S TOP 10 STORIES OF 2006
7. Drug approvals — with strings attached. Hopes were high when natalizumab (Tysabri) was introduced in 2004. The new monoclonal antibody treatment promised to treat multiple sclerosis by binding to immune system cells that attack the myelin covering of nerves in the brain and spinal cord. The crash landing came a few months later: Tysabri was withdrawn after being linked to three cases of an unusual brain infection (progressive multifocal leukoencephalopathy).
In 2006, the FDA allowed the drug back on the market, with restrictions. Doctors prescribing it must register with the manufacturer. The monthly infusions can only be given at authorized sites. Patients must also be registered in a special Tysabri program. Alosetron (Lotronex), the irritable bowel syndrome drug, followed a similar path earlier: The big splash, the hasty retreat off the market, a return with restrictions.
Drug approvals have generally been binary, yea or nay, with doctors free to prescribe any approved drug. With Tysabri and Lotronex, we’re moving toward modified approvals with requirements for monitoring attached.
7. Drug approvals — with strings attached. Hopes were high when natalizumab (Tysabri) was introduced in 2004. The new monoclonal antibody treatment promised to treat multiple sclerosis by binding to immune system cells that attack the myelin covering of nerves in the brain and spinal cord. The crash landing came a few months later: Tysabri was withdrawn after being linked to three cases of an unusual brain infection (progressive multifocal leukoencephalopathy).
In 2006, the FDA allowed the drug back on the market, with restrictions. Doctors prescribing it must register with the manufacturer. The monthly infusions can only be given at authorized sites. Patients must also be registered in a special Tysabri program. Alosetron (Lotronex), the irritable bowel syndrome drug, followed a similar path earlier: The big splash, the hasty retreat off the market, a return with restrictions.
Drug approvals have generally been binary, yea or nay, with doctors free to prescribe any approved drug. With Tysabri and Lotronex, we’re moving toward modified approvals with requirements for monitoring attached.
2006 WAS A GOOD YEAR FOR MS:
During 2006, rapid research progress was made in the fields of science and medicine that impact understanding and treatment of multiple sclerosis, an unpredictable neurological disease.
Significant advances have been made in both clinical and laboratory studies in MS. In addition, more than 130 clinical trials are underway around the world, and still other experimental drugs are in the pipeline. Key highlights of the year include:
Acorda Therapeutics (Hawthorne, NY) announced positive results of a Phase 3, placebo-controlled clinical trial of Fampridine-SR, an oral drug designed to provide symptomatic relief by compensating for lost nerve conduction. In 301 patients with all types of MS, those on active treatment showed an average increase in walking speed of 25% versus those on inactive placebo. The company is expected to meet with the U.S. Food and Drug Administration (FDA) to determine next steps needed to apply for marketing approval.
The FDA approved the return to market of Tysabri(R) (natalizumab, produced by Biogen Idec and Elan Pharmaceuticals) to delay the accumulation of physical disability and reduce the frequency of relapses (clinical exacerbations) in those with relapsing MS. There is now in place a mandatory registration program for patients and prescribing physicians to minimize the risk of PML (progressive multifocal leukoencephalopathy), caused by a common virus called the JC virus. The drug is dispensed at registered infusion centers across the country. Since Tysabri's return to market last summer, there have been no new cases of PML reported.
Members of the four Nervous System Repair teams from Europe and the U.S. met to share progress being made in the Society funded Promise: 2010 initiative. The first clinical trials focused on protecting the nervous system will begin shortly, and trials aimed at repairing damage and restoring function in people with MS are expected to begin within the next five years.
In a first, Johns Hopkins University researchers reported that nerve cells derived from mouse embryonic stem cells that were transplanted into rats with spinal cord injury were able to connect with muscles and partially restore function. While this work was done in a model of spinal cord injury, it bears relevance to the potential use of cell replacement to repair damage in MS.
The Society will be sponsoring the first ever stem cell summit January 16-19 in San Francisco to explore the potential of the complete spectrum of stem cell options as they might relate to MS research and treatment. The by-invitation only meeting will bring together some 60 renowned scientists from around the world to examine stem cell prospects and strategies in MS. The results of this meeting are expected to set research directions and priorities to best determine the potential of all types of stem cells for treating this disease.
Researchers from the University of California, Los Angeles reported that administering Androgel(R) (testosterone gel applied to the skin) to 10 men with relapsing-remitting MS significantly improved cognitive function and slowed brain tissue loss. This study was funded by the Society's initiative on Gender Differences in MS and is expected to lead to additional research involving larger numbers of patients to confirm these early results.
In another offshoot from the Society's initiative on Gender Differences, UCLA investigators began the first large-scale trial of a sex hormone for the treatment of MS. The two-year, controlled clinical trial of estriol involves 130 women with early relapsing-remitting MS. If successful, this clinical trial will lay the groundwork for a larger, definitive trial that could lead to a new treatment option for women with MS. Its results may also have implications for women with other autoimmune diseases, such as rheumatoid arthritis.
Several oral MS therapies continued to progress through the pipeline:
-- a phase II controlled clinical trial of oral fingolimod (FTY720, Novartis Pharmaceuticals Corp.) in 255 people with active, relapsing MS found that up to 77% of those taking fingolimod remained free of relapses over two years; a large phase III trial is now underway;
-- oral cladribine (an immune-modulating drug by Serono), now being tested in an international Phase 3 clinical trial, has been designated by the FDA as a "Fast Track Product," which should expedite its future review;
-- a multicenter, phase II controlled clinical trial of oral BG00012 (an oral fumarate, Biogen Idec) led to a 69% reduction in active inflammation on MRI scans in 257 people with relapsing-remitting MS;
-- in an open-label, 144-week extension study of oral teriflunomide (an agent that may modulate T cells), those on placebo during the original trial who switched to teriflunomide experienced up to an 85% decrease in new, active areas of disease activity seen on MRI at week 144.
Harvard investigators reported that individuals who showed signs of significant exposure to the Epstein-Barr virus, which causes infectious mononucleosis and other disorders, were twice as likely to develop MS up to 20 years later. The study, funded in part by a grant from the National MS Society, adds to previous evidence linking the virus to the risk of developing MS, but does not prove that EBV actually causes MS. Other recent studies have suggested that smoking cigarettes may contribute to the risk of MS and MS progression, and that higher vitamin D intake may help protect against developing MS.
For the first time, the needs of children who develop MS-like symptoms are being addressed through the Society's nationwide network of comprehensive Pediatric MS Centers of Excellence, launched early this year. The 6 centers have committed to sharing critical resources and best practices such as MRI protocols and neuropsychological evaluations so that all families can benefit from the collective knowledge of the entire network. In addition to providing optimal care and support, these centers will build a framework for research into this patient population, which may also provide clues to adult MS.
Two genes that may contribute to making a person susceptible to developing MS have been identified by a group of European researchers known as the "GAMES" Collaborative Group. MS involves an immune-system attack on the body's own brain and spinal cord, and many genes are thought to contribute to susceptibility. The two candidate genes were singled out because they encode for a brain tissue component and an immune component. This work was supported in part by the National MS Society.
Researchers at Stanford University have uncovered evidence they believe may explain the role of a protein, osteopontin, in stimulating repeated relapses and disease progression as well as inhibiting spontaneous recovery from symptoms. This research, sponsored in part by the Society, could lead to new therapeutic approaches that target oseopontin's effect in the MS disease process.
The National MS Society launched a new postdoctoral fellowship program in MS rehabilitation research. The immediate goal is to recruit and train talented clinician-scientists in rehabilitation research specific to MS; the ultimate goal is to get more hands and minds working on ways to help people with MS maximize their abilities.
[SOURCE: MS SOCIETY]
During 2006, rapid research progress was made in the fields of science and medicine that impact understanding and treatment of multiple sclerosis, an unpredictable neurological disease.
Significant advances have been made in both clinical and laboratory studies in MS. In addition, more than 130 clinical trials are underway around the world, and still other experimental drugs are in the pipeline. Key highlights of the year include:
Acorda Therapeutics (Hawthorne, NY) announced positive results of a Phase 3, placebo-controlled clinical trial of Fampridine-SR, an oral drug designed to provide symptomatic relief by compensating for lost nerve conduction. In 301 patients with all types of MS, those on active treatment showed an average increase in walking speed of 25% versus those on inactive placebo. The company is expected to meet with the U.S. Food and Drug Administration (FDA) to determine next steps needed to apply for marketing approval.
The FDA approved the return to market of Tysabri(R) (natalizumab, produced by Biogen Idec and Elan Pharmaceuticals) to delay the accumulation of physical disability and reduce the frequency of relapses (clinical exacerbations) in those with relapsing MS. There is now in place a mandatory registration program for patients and prescribing physicians to minimize the risk of PML (progressive multifocal leukoencephalopathy), caused by a common virus called the JC virus. The drug is dispensed at registered infusion centers across the country. Since Tysabri's return to market last summer, there have been no new cases of PML reported.
Members of the four Nervous System Repair teams from Europe and the U.S. met to share progress being made in the Society funded Promise: 2010 initiative. The first clinical trials focused on protecting the nervous system will begin shortly, and trials aimed at repairing damage and restoring function in people with MS are expected to begin within the next five years.
In a first, Johns Hopkins University researchers reported that nerve cells derived from mouse embryonic stem cells that were transplanted into rats with spinal cord injury were able to connect with muscles and partially restore function. While this work was done in a model of spinal cord injury, it bears relevance to the potential use of cell replacement to repair damage in MS.
The Society will be sponsoring the first ever stem cell summit January 16-19 in San Francisco to explore the potential of the complete spectrum of stem cell options as they might relate to MS research and treatment. The by-invitation only meeting will bring together some 60 renowned scientists from around the world to examine stem cell prospects and strategies in MS. The results of this meeting are expected to set research directions and priorities to best determine the potential of all types of stem cells for treating this disease.
Researchers from the University of California, Los Angeles reported that administering Androgel(R) (testosterone gel applied to the skin) to 10 men with relapsing-remitting MS significantly improved cognitive function and slowed brain tissue loss. This study was funded by the Society's initiative on Gender Differences in MS and is expected to lead to additional research involving larger numbers of patients to confirm these early results.
In another offshoot from the Society's initiative on Gender Differences, UCLA investigators began the first large-scale trial of a sex hormone for the treatment of MS. The two-year, controlled clinical trial of estriol involves 130 women with early relapsing-remitting MS. If successful, this clinical trial will lay the groundwork for a larger, definitive trial that could lead to a new treatment option for women with MS. Its results may also have implications for women with other autoimmune diseases, such as rheumatoid arthritis.
Several oral MS therapies continued to progress through the pipeline:
-- a phase II controlled clinical trial of oral fingolimod (FTY720, Novartis Pharmaceuticals Corp.) in 255 people with active, relapsing MS found that up to 77% of those taking fingolimod remained free of relapses over two years; a large phase III trial is now underway;
-- oral cladribine (an immune-modulating drug by Serono), now being tested in an international Phase 3 clinical trial, has been designated by the FDA as a "Fast Track Product," which should expedite its future review;
-- a multicenter, phase II controlled clinical trial of oral BG00012 (an oral fumarate, Biogen Idec) led to a 69% reduction in active inflammation on MRI scans in 257 people with relapsing-remitting MS;
-- in an open-label, 144-week extension study of oral teriflunomide (an agent that may modulate T cells), those on placebo during the original trial who switched to teriflunomide experienced up to an 85% decrease in new, active areas of disease activity seen on MRI at week 144.
Harvard investigators reported that individuals who showed signs of significant exposure to the Epstein-Barr virus, which causes infectious mononucleosis and other disorders, were twice as likely to develop MS up to 20 years later. The study, funded in part by a grant from the National MS Society, adds to previous evidence linking the virus to the risk of developing MS, but does not prove that EBV actually causes MS. Other recent studies have suggested that smoking cigarettes may contribute to the risk of MS and MS progression, and that higher vitamin D intake may help protect against developing MS.
For the first time, the needs of children who develop MS-like symptoms are being addressed through the Society's nationwide network of comprehensive Pediatric MS Centers of Excellence, launched early this year. The 6 centers have committed to sharing critical resources and best practices such as MRI protocols and neuropsychological evaluations so that all families can benefit from the collective knowledge of the entire network. In addition to providing optimal care and support, these centers will build a framework for research into this patient population, which may also provide clues to adult MS.
Two genes that may contribute to making a person susceptible to developing MS have been identified by a group of European researchers known as the "GAMES" Collaborative Group. MS involves an immune-system attack on the body's own brain and spinal cord, and many genes are thought to contribute to susceptibility. The two candidate genes were singled out because they encode for a brain tissue component and an immune component. This work was supported in part by the National MS Society.
Researchers at Stanford University have uncovered evidence they believe may explain the role of a protein, osteopontin, in stimulating repeated relapses and disease progression as well as inhibiting spontaneous recovery from symptoms. This research, sponsored in part by the Society, could lead to new therapeutic approaches that target oseopontin's effect in the MS disease process.
The National MS Society launched a new postdoctoral fellowship program in MS rehabilitation research. The immediate goal is to recruit and train talented clinician-scientists in rehabilitation research specific to MS; the ultimate goal is to get more hands and minds working on ways to help people with MS maximize their abilities.
[SOURCE: MS SOCIETY]
Biogen issues alert after 2 Rituxan deaths- The Boston Globe
By Stephen Heuser, Globe Staff | December 19, 2006
Biogen Idec Inc. said yesterday that two patients using its drug Rituxan have died of a rare brain infection, the same one that shadows its multiple sclerosis treatment Tysabri .
In a letter sent to doctors, Biogen and Genentech Inc., which co-markets Rituxan with the Cambridge drug maker, warned that the two patients had contracted fatal progressive multifocal leukoencephalopathy, or PML.MORE: The Boston Globe
By Stephen Heuser, Globe Staff | December 19, 2006
Biogen Idec Inc. said yesterday that two patients using its drug Rituxan have died of a rare brain infection, the same one that shadows its multiple sclerosis treatment Tysabri .
In a letter sent to doctors, Biogen and Genentech Inc., which co-markets Rituxan with the Cambridge drug maker, warned that the two patients had contracted fatal progressive multifocal leukoencephalopathy, or PML.MORE: The Boston Globe
TYSABRI: "Biologic treatment for MS offers hope": Daytona Beach News-Journal
December 18, 2006
Biologic treatment for MS offers hope
By DR. YONG H. TSAI
Susan awoke one day with blurred, obstructed vision along with dizziness and numbness in her legs. A trip to her doctor's office triggered an order for blood tests and an MRI. She was diagnosed with multiple sclerosis (MS), an autoimmune disease involving the central nervous system.
Our brain and spinal cord, that house the main pathway of our body's nerve signals, offer a layer of insulation, called myelin, that surrounds and protects these nerve cells.
Like a plastic cover that surrounds the many wires of an electric cable, myelin covers nerve fibers to ensure that the nerve signals have safe, uninterrupted passage.
With MS, myelin sheaths break down (demyelination), due to inflammation caused by the autoimmune process. Damaged tissue eventually turns into scar tissue (sclerosis), meaning "multiple sclerosis."
Classic symptoms of MS include numbness, visual disturbance, abnormal gait, imbalance, muscle weakness or spasm, urinary incontinence, vertigo, slurred speech and even pain.
There are several forms of MS. Relapsing-remitting MS (RRMS) occurs about 25 percent of the time with intermittent relapses, including worsening of existing symptoms or the development of new ones.
Over the course of 10 to 15 years, more than 50 percent of RRMS will evolve into progressive MS, known for more frequent relapses, incomplete remission bouts and general overall deterioration.
During the past few years, beta interferons such as Avonex, Rebif, Betaseron and Copaxone, by modifying the inflammatory process, have been used to treat MS.
However, all still have side effects and some have poor results. In November 2005, Natalizumab (Tysabri), a biologic agent, was proven to block the function of key molecules. The process could transport immune cells crossing the brain and blood barrier (BBB), and prevent against an attack on one's central nervous system.
Clinical trials have shown Tysabri, administered by monthly intravenous infusion, is a very effective therapy in reducing relapses and decreasing new brain lesions.
However, the shocking news surfaced Feb. 28 that Tysabri was suspended temporarily from commercial distribution due to three serious, adverse events. Multifocal leukoencephalopathy (PML) occurred in clinical trial patients treated with Tysabri plus Avonex.
However, there have been no reports of PML in patients treated with either Tysabri or Avonex alone.
More recently, Tysabri has been permitted for MS treatment. Tysabri is only indicated as a single-agent treatment instead of in combined therapy with Avonex or other agents. It's for patients with the relapsing form of MS and poor response to traditional treatments.
Though there is some concern with rare side effects of Tysabri, this new biologic agent offers new hope.
December 18, 2006
Biologic treatment for MS offers hope
By DR. YONG H. TSAI
Susan awoke one day with blurred, obstructed vision along with dizziness and numbness in her legs. A trip to her doctor's office triggered an order for blood tests and an MRI. She was diagnosed with multiple sclerosis (MS), an autoimmune disease involving the central nervous system.
Our brain and spinal cord, that house the main pathway of our body's nerve signals, offer a layer of insulation, called myelin, that surrounds and protects these nerve cells.
Like a plastic cover that surrounds the many wires of an electric cable, myelin covers nerve fibers to ensure that the nerve signals have safe, uninterrupted passage.
With MS, myelin sheaths break down (demyelination), due to inflammation caused by the autoimmune process. Damaged tissue eventually turns into scar tissue (sclerosis), meaning "multiple sclerosis."
Classic symptoms of MS include numbness, visual disturbance, abnormal gait, imbalance, muscle weakness or spasm, urinary incontinence, vertigo, slurred speech and even pain.
There are several forms of MS. Relapsing-remitting MS (RRMS) occurs about 25 percent of the time with intermittent relapses, including worsening of existing symptoms or the development of new ones.
Over the course of 10 to 15 years, more than 50 percent of RRMS will evolve into progressive MS, known for more frequent relapses, incomplete remission bouts and general overall deterioration.
During the past few years, beta interferons such as Avonex, Rebif, Betaseron and Copaxone, by modifying the inflammatory process, have been used to treat MS.
However, all still have side effects and some have poor results. In November 2005, Natalizumab (Tysabri), a biologic agent, was proven to block the function of key molecules. The process could transport immune cells crossing the brain and blood barrier (BBB), and prevent against an attack on one's central nervous system.
Clinical trials have shown Tysabri, administered by monthly intravenous infusion, is a very effective therapy in reducing relapses and decreasing new brain lesions.
However, the shocking news surfaced Feb. 28 that Tysabri was suspended temporarily from commercial distribution due to three serious, adverse events. Multifocal leukoencephalopathy (PML) occurred in clinical trial patients treated with Tysabri plus Avonex.
However, there have been no reports of PML in patients treated with either Tysabri or Avonex alone.
More recently, Tysabri has been permitted for MS treatment. Tysabri is only indicated as a single-agent treatment instead of in combined therapy with Avonex or other agents. It's for patients with the relapsing form of MS and poor response to traditional treatments.
Though there is some concern with rare side effects of Tysabri, this new biologic agent offers new hope.
Elan, Biogen Idec submit Tysabri for Crohns - Pharmaceutical Business Review
Elan and Biogen Idec have submitted a biologics license application to the FDA seeking approval to market Tysabri in the US as a treatment for Crohn's disease.MORE
Elan and Biogen Idec have submitted a biologics license application to the FDA seeking approval to market Tysabri in the US as a treatment for Crohn's disease.MORE
Cost vs quality of life - UK EDITORIAL - The Herald
Scotland has, unfortunately, written itself into the MS textbooks because it has the highest proportion of people suffering from the degenerative condition in the world. Why this should be so is not clear. MS has ill-defined genetic links that do not point to a recognisable hereditary pattern. But it seems there might be links between climate, the effects of smoking and MS.
Since science has yet to uncover what causes MS, a process which, when successfully completed, should open the door on a cure, it is imperative that treatments are developed and made available to improve the outlook for patients (in Scotland there are more than 10,400 with the condition). Drugs are available on prescription that reduce the frequency and severity of attacks. One drug, Tysabri, has been licensed for use in Britain, the United States and Europe which has been proved to be effective in alleviating the impact of some of the most severe forms of MS. It is estimated that some 10% of MS sufferers in Scotland could benefit from receiving Tysabri on prescription.
However, the Scottish Medicines Consortium (SMC) decided yesterday that the drug should not be prescribed on the NHS. Its reasons were economic. Tysabri costs some £15,000 a year for each patient. Prescribing the drug
Scotland has, unfortunately, written itself into the MS textbooks because it has the highest proportion of people suffering from the degenerative condition in the world. Why this should be so is not clear. MS has ill-defined genetic links that do not point to a recognisable hereditary pattern. But it seems there might be links between climate, the effects of smoking and MS.
Since science has yet to uncover what causes MS, a process which, when successfully completed, should open the door on a cure, it is imperative that treatments are developed and made available to improve the outlook for patients (in Scotland there are more than 10,400 with the condition). Drugs are available on prescription that reduce the frequency and severity of attacks. One drug, Tysabri, has been licensed for use in Britain, the United States and Europe which has been proved to be effective in alleviating the impact of some of the most severe forms of MS. It is estimated that some 10% of MS sufferers in Scotland could benefit from receiving Tysabri on prescription.
However, the Scottish Medicines Consortium (SMC) decided yesterday that the drug should not be prescribed on the NHS. Its reasons were economic. Tysabri costs some £15,000 a year for each patient. Prescribing the drug
Dismay over decision: NO TSABRI FOR 1000 PATIENTS: BBC NEWS
Multiple sclerosis charities have said they are "bitterly disappointed" at a decision not to prescribe Tysabri in Scotland...But the Scottish Medicines Consortium said the economic case for the drug had not been demonstrated
SMC decisions are based on cost-effectiveness, using the cost per quality adjusted life year (QALY), which tries to determine the value of a treatment to a person's life, rather than the actual cost of providing the drug.
"Accountancy has trumped clinical evidence with this decision," Mr Jones added.
"For a well-defined group of people with MS, where the disease is running out of control, this drug is highly effective, leading to 60-70% reductions in relapses. Only an economist could make that sound expensive." MORE: BBC NEWS
Multiple sclerosis charities have said they are "bitterly disappointed" at a decision not to prescribe Tysabri in Scotland...But the Scottish Medicines Consortium said the economic case for the drug had not been demonstrated
SMC decisions are based on cost-effectiveness, using the cost per quality adjusted life year (QALY), which tries to determine the value of a treatment to a person's life, rather than the actual cost of providing the drug.
"Accountancy has trumped clinical evidence with this decision," Mr Jones added.
"For a well-defined group of people with MS, where the disease is running out of control, this drug is highly effective, leading to 60-70% reductions in relapses. Only an economist could make that sound expensive." MORE: BBC NEWS
Multiple Sclerosis Charity 'Bitterly Disappointed' at Tysabri No
"LONDON, December 11 -- The MS Society is 'bitterly disappointed' after the Scottish Medicines Consortium (SMC) advised health professionals not to prescribe Tysabri - the only drug licensed for multiple sclerosis (MS) that has shown significant promise in slowing the progression of disability.
Reacting to today's announcement, Mark Hazelwood, Director of the MS Society Scotland, said: "We are bitterly disappointed that the SMC has decided not to fund Tysabri on the NHS, despite acknowledging that the clinical case was sound. This means people with the most aggressive form of relapsing remitting MS now have little or no option.
"No other drug has shown this potential to reduce disability, and any short-term savings are likely to be outpaced by the devastating financial costs of living with severe, progressive disability - not to mention the emotional costs to people with MS and their friends and families."
For people with severe relapsing remitting MS who do not respond to beta interferon, or to glatiramer acetate, there had been no licensed and effective treatment options until now. Tysabri had been welcomed as an important breakthrough and compared with current treatments had shown an impressive reduction in relapse rates and a significant reduction in the risk of disability progression.MORE
"LONDON, December 11 -- The MS Society is 'bitterly disappointed' after the Scottish Medicines Consortium (SMC) advised health professionals not to prescribe Tysabri - the only drug licensed for multiple sclerosis (MS) that has shown significant promise in slowing the progression of disability.
Reacting to today's announcement, Mark Hazelwood, Director of the MS Society Scotland, said: "We are bitterly disappointed that the SMC has decided not to fund Tysabri on the NHS, despite acknowledging that the clinical case was sound. This means people with the most aggressive form of relapsing remitting MS now have little or no option.
"No other drug has shown this potential to reduce disability, and any short-term savings are likely to be outpaced by the devastating financial costs of living with severe, progressive disability - not to mention the emotional costs to people with MS and their friends and families."
For people with severe relapsing remitting MS who do not respond to beta interferon, or to glatiramer acetate, there had been no licensed and effective treatment options until now. Tysabri had been welcomed as an important breakthrough and compared with current treatments had shown an impressive reduction in relapse rates and a significant reduction in the risk of disability progression.MORE
TYSABRI & AVONEX: Interview with Biogen Chief executive James C. Mullen - The Boston Globe
For Biogen Idec Inc., the return of the multiple sclerosis drug Tysabri to the market and continued sales growth for its cash cow, Avonex, were the highlights of 2006.
Q How is Biogen Idec doing?
A In spite of the trials and tribulations of 2005 (when sales of Tysabri were suspended), the actual financial results were fine. In 2006, we continue to accelerate on that. Tysabri has made its way back to the market. People are still obsessed with how many prescriptions we have today. That will take care of itself over time. It's on the market in the US and Europe.
Q What percentage of revenue and profits come from Avonex?
A It's probably in the range of a little over 50 percent on both revenues and profits. Rituxan and Avonex generate the bulk of revenues and profits.
Q Are prescriptions of Tysabri, which Biogen markets with Elan Corp., robust enough to become a significant financial contributor?
A Tysabri will become a significant contributor. It won't be this year because it's just getting going. Unless it hits a major pothole like it hit before, it will probably eclipse Avonex over time. People have generally lost sight of Tysabri outside of multiple sclerosis.
MORE- The Boston Globe
For Biogen Idec Inc., the return of the multiple sclerosis drug Tysabri to the market and continued sales growth for its cash cow, Avonex, were the highlights of 2006.
Q How is Biogen Idec doing?
A In spite of the trials and tribulations of 2005 (when sales of Tysabri were suspended), the actual financial results were fine. In 2006, we continue to accelerate on that. Tysabri has made its way back to the market. People are still obsessed with how many prescriptions we have today. That will take care of itself over time. It's on the market in the US and Europe.
Q What percentage of revenue and profits come from Avonex?
A It's probably in the range of a little over 50 percent on both revenues and profits. Rituxan and Avonex generate the bulk of revenues and profits.
Q Are prescriptions of Tysabri, which Biogen markets with Elan Corp., robust enough to become a significant financial contributor?
A Tysabri will become a significant contributor. It won't be this year because it's just getting going. Unless it hits a major pothole like it hit before, it will probably eclipse Avonex over time. People have generally lost sight of Tysabri outside of multiple sclerosis.
MORE- The Boston Globe
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